2100850-28-8

2100850-28-8 structure

Name: APJ receptor agonist 7
Chemical Name: APJ receptor agonist 7
CAS Number: 2100850-28-8
Molecular Formula: C₃₂H₄₆N₄O₄
Molecular Weight: 550.73
Catalog: Research Areas Cardiovascular Disease
Create Date: 2022-09-01 15:42:27
Modify Date: 2024-01-14 10:55:39
APJ receptor agonist 7 (compound 37) is a potent and orally active APJ (apelin receptor) agonist, with Ki of 0.059 μM. APJ receptor agonist 7 has EC50 values of 0.070 , 0.097, and 0.063 μM for calcium, cAMP, and β-arrestin, respectively[1].

Name	APJ receptor agonist 7

Description	APJ receptor agonist 7 (compound 37) is a potent and orally active APJ (apelin receptor) agonist, with Ki of 0.059 μM. APJ receptor agonist 7 has EC50 values of 0.070 , 0.097, and 0.063 μM for calcium, cAMP, and β-arrestin, respectively[1].
Related Catalog	Research Areas >> Cardiovascular Disease
Target	EC50: 0.063 ± 0.004 μM (Apelin Receptor β-arrestin), 0.070 ± 0.009 μM (Apelin Receptor calcium), 0.097 ± 0.032 μM (Apelin Receptor cAMP), >10 μM (AT1 calcium)[1]
References	[1]. Narayanan S, et al. Identification of potent pyrazole based APELIN receptor (APJ) agonists. Bioorg Med Chem. 2020 Feb 15;28(4):115237.

Molecular Formula	C₃₂H₄₆N₄O₄
Molecular Weight	550.73