ADRA1D receptor agonist 1

Modify Date: 2024-01-11 11:28:03

ADRA1D receptor agonist 1 structure	Common Name	ADRA1D receptor agonist 1
	CAS Number	1191908-14-1	Molecular Weight	337.20
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₅H₁₄Cl₂N₄O	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of ADRA1D receptor agonist 1

ADRA1D receptor agonist 1 (compound (R)-9S) is a potent, selective and orally active α1D adrenoceptor antagonist, with a Ki of 1.6 nM[1].

Name	ADRA1D receptor agonist 1

Description	ADRA1D receptor agonist 1 (compound (R)-9S) is a potent, selective and orally active α1D adrenoceptor antagonist, with a Ki of 1.6 nM[1].
Related Catalog	Research Areas >> Endocrinology Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor
Target	Ki: 1.6 nM (α1D adrenoceptor)[1]
In Vitro	ADRA1D receptor agonist 1 shows low hERG inhibition[1]. ADRA1D receptor agonist 1 exhibits higher selectivity for α1D-AR over α1A- and α1B-ARs [1].
In Vivo	ADRA1D receptor agonist 1 (4.4 µg/kg; i.v.) dose-dependently decreases the non-voiding bladder contractions during the urinary storage phase in rats with BOO[1]. Animal Model: Rat with bladder outlet obstruction (BOO)[1] Dosage: 4.4 µg/kg Administration: Intravenous injection Result: Dose-dependently decreased the non-voiding bladder contractions during urinary storage phase in rats with BOO.
References	[1]. Sakauchi N, et al. Discovery of 5-Chloro-1-(5-chloro-2-(methylsulfonyl)benzyl)-2-imino-1,2-dihydropyridine-3-carboxamide (TAK-259) as a Novel, Selective, and Orally Active α1D Adrenoceptor Antagonist with Antiurinary Frequency Effects: Reducing Human Ether-a-go-go-Related Gene (hERG) Liabilities. J Med Chem. 2016 Apr 14;59(7):2989-3002.

Molecular Formula	C₁₅H₁₄Cl₂N₄O
Molecular Weight	337.20

DC Chemicals Limited
China
Product Name: ADRA1D receptor agonist 1
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Purity: 98.0%
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