477775-14-7

477775-14-7 structure

Name: AT2 receptor agonist C21
Chemical Name: compound 21 [PMID: 22802221]
CAS Number: 477775-14-7
Molecular Formula: C₂₃H₂₉N₃O₄S₂
Molecular Weight: 475.624
Catalog: Research Areas Endocrinology
Create Date: 2018-06-07 06:55:59
Modify Date: 2024-01-09 18:30:07
AT2 receptor agonist C21 is a druglike selective angiotensin II AT2 receptor agonist with Ki values of 0.4 nM and >10 µM for the AT2 receptor and AT1 receptor, respectively[1].

Name	compound 21 [PMID: 22802221]
Synonyms	Butyl ({3-[4-(1H-imidazol-1-ylmethyl)phenyl]-5-isobutyl-2-thienyl}sulfonyl)carbamate butyl ({3-[4-(1H-imidazol-1-ylmethyl)phenyl]-5-(2-methylpropyl)thiophen-2-yl}sulfonyl)carbamate compound 21 [PMID: 22802221] Carbamic acid, N-[[3-[4-(1H-imidazol-1-ylmethyl)phenyl]-5-(2-methylpropyl)-2-thienyl]sulfonyl]-, butyl ester N-butyloxycarbonyl-3-(4-imidazol-1-ylmethylphenyl)-5-isobutylthiophene-2-sulfonamide

Description	AT2 receptor agonist C21 is a druglike selective angiotensin II AT2 receptor agonist with Ki values of 0.4 nM and >10 µM for the AT2 receptor and AT1 receptor, respectively[1].
Related Catalog	Research Areas >> Endocrinology
Target	Ki: 0.4 nM (AT2) and >10 µM (AT1)[1]
In Vivo	AT2 receptor agonist C21, with a bioavailability of 20-30% after oral administration and a half-life estimated to 4 h in rat, induces outgrowth of neurite cells, stimulates p42/p44mapk, enhances in vivo duodenal alkaline secretion in Sprague-Dawley rats, and lowers the mean arterial blood pressure in anesthetized, spontaneously hypertensive rats[1].
References	[1]. Wan Y, et al. Design, synthesis, and biological evaluation of the first selective nonpeptide AT2 receptor agonist. J Med Chem. 2004 Nov 18;47(24):5995-6008.