α7 nAchR-JAK2-STAT3 agonist 1

Modify Date: 2025-08-23 20:05:47

α7 nAchR-JAK2-STAT3 agonist 1 structure	Common Name	α7 nAchR-JAK2-STAT3 agonist 1
	CAS Number	2108714-20-9	Molecular Weight	426.50
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₅H₃₀O₆	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of α7 nAchR-JAK2-STAT3 agonist 1

α7 nAchR-JAK2-STAT3 agonist 1 is a potent α7 nAchR-JAK2-STAT3 agonist, with an IC50 value of 0.32 μM for nitric oxide (NO). α7 nAchR-JAK2-STAT3 agonist 1 effectively suppresses the expression of iNOS, IL-1β, and IL-6 in murine RAW264.7 macrophages. α7 nAchR-JAK2-STAT3 agonist 1 can inhibit LPS-induced NO release, NF-κB activation and cytokine production. α7 nAchR-JAK2-STAT3 can be used for researching sepsis[1].

Name	α7 nAchR-JAK2-STAT3 agonist 1

Description	α7 nAchR-JAK2-STAT3 agonist 1 is a potent α7 nAchR-JAK2-STAT3 agonist, with an IC50 value of 0.32 μM for nitric oxide (NO). α7 nAchR-JAK2-STAT3 agonist 1 effectively suppresses the expression of iNOS, IL-1β, and IL-6 in murine RAW264.7 macrophages. α7 nAchR-JAK2-STAT3 agonist 1 can inhibit LPS-induced NO release, NF-κB activation and cytokine production. α7 nAchR-JAK2-STAT3 can be used for researching sepsis[1].
Related Catalog	Signaling Pathways >> Stem Cell/Wnt >> STAT Signaling Pathways >> JAK/STAT Signaling >> JAK Signaling Pathways >> Epigenetics >> JAK Signaling Pathways >> Stem Cell/Wnt >> JAK Signaling Pathways >> JAK/STAT Signaling >> STAT Signaling Pathways >> Immunology/Inflammation >> NO Synthase Signaling Pathways >> Membrane Transporter/Ion Channel >> nAChR Signaling Pathways >> Neuronal Signaling >> nAChR Research Areas >> Inflammation/Immunology
Target	IC50: 0.32 μM (NO)[1]
References	[1]. Lin Y, et al. Discovery of diarylheptanoids that activate α7 nAchR-JAK2-STAT3 signaling in macrophages with anti-inflammatory activity in vitro and in vivo. Bioorg Med Chem. 2022;66:116811.

Molecular Formula	C₂₅H₃₀O₆
Molecular Weight	426.50

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α7 nAchR-JAK2-STAT3 agonist 1

Use of α7 nAchR-JAK2-STAT3 agonist 1

Names

α7 nAchR-JAK2-STAT3 agonist 1 Biological Activity

Chemical & Physical Properties

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.