886358-51-6

886358-51-6 structure

Name: FFA3 agonist 1
Chemical Name: 4-(Furan-2-yl)-2-methyl-5-oxo-N-(o-tolyl)-1,4,5,6,7,8-hexahydroquinoline-3-carboxamide
CAS Number: 886358-51-6
Molecular Formula: C₂₂H₂₂N₂O₃
Molecular Weight: 362.42
Catalog: Signaling Pathways GPCR/G Protein GPR40
Create Date: 2022-09-29 22:43:58
Modify Date: 2024-01-11 19:59:14
FFA3 agonist 1 (Compound 24) is an agonist of free fatty acid receptor 3 (FFA3). FFA3 agonist 1 regulates the health effect of intestinal microbiota by activating FFA3[1].

Name	4-(Furan-2-yl)-2-methyl-5-oxo-N-(o-tolyl)-1,4,5,6,7,8-hexahydroquinoline-3-carboxamide

Description	FFA3 agonist 1 (Compound 24) is an agonist of free fatty acid receptor 3 (FFA3). FFA3 agonist 1 regulates the health effect of intestinal microbiota by activating FFA3[1].
Related Catalog	Research Areas >> Inflammation/Immunology Signaling Pathways >> GPCR/G Protein >> GPR40 Research Areas >> Metabolic Disease
In Vitro	FFA3 agonist 1 增加诱导表达增强黄色荧光蛋白 (eYFP) 人游离脂肪酸受体 3 (hFFA3) 的 Flp-in-T-REx 293细胞中的 [35S]GTPgS 的掺入和 pERK1/2 的产生，减少中 cAMP 的产生[2]。 FFA3 agonist 1 增加人游离脂肪酸受体 3、鼠游离脂肪酸受体 3 (mFFA3)、兔游离脂肪酸受体 3 (rFFA3) 中 [35S]GTPgS 的掺入[2]。
References	[1]. Ulven ER, et al. Structure-Activity Relationship Studies of Tetrahydroquinolone Free Fatty Acid Receptor 3 Modulators. J Med Chem. 2020 Apr 9;63(7):3577-3595. [2]. Hudson BD, Christiansen E, Murdoch H, Jenkins L, Hansen AH, Madsen O, Ulven T, Milligan G. Complex pharmacology of novel allosteric free fatty acid 3 receptor ligands. Mol Pharmacol. 2014 Aug;86(2):200-10.

Molecular Formula	C₂₂H₂₂N₂O₃
Molecular Weight	362.42