FFA3 agonist 1

Modify Date: 2025-10-03 17:00:12

FFA3 agonist 1 structure	Common Name	FFA3 agonist 1
	CAS Number	886358-51-6	Molecular Weight	362.42
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₂H₂₂N₂O₃	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of FFA3 agonist 1

FFA3 agonist 1 (Compound 24) is an agonist of free fatty acid receptor 3 (FFA3). FFA3 agonist 1 regulates the health effect of intestinal microbiota by activating FFA3[1].

Name	4-(Furan-2-yl)-2-methyl-5-oxo-N-(o-tolyl)-1,4,5,6,7,8-hexahydroquinoline-3-carboxamide

Description	FFA3 agonist 1 (Compound 24) is an agonist of free fatty acid receptor 3 (FFA3). FFA3 agonist 1 regulates the health effect of intestinal microbiota by activating FFA3[1].
Related Catalog	Research Areas >> Inflammation/Immunology Signaling Pathways >> GPCR/G Protein >> GPR40 Research Areas >> Metabolic Disease
In Vitro	FFA3 agonist 1 增加诱导表达增强黄色荧光蛋白 (eYFP) 人游离脂肪酸受体 3 (hFFA3) 的 Flp-in-T-REx 293细胞中的 [35S]GTPgS 的掺入和 pERK1/2 的产生，减少中 cAMP 的产生[2]。 FFA3 agonist 1 增加人游离脂肪酸受体 3、鼠游离脂肪酸受体 3 (mFFA3)、兔游离脂肪酸受体 3 (rFFA3) 中 [35S]GTPgS 的掺入[2]。
References	[1]. Ulven ER, et al. Structure-Activity Relationship Studies of Tetrahydroquinolone Free Fatty Acid Receptor 3 Modulators. J Med Chem. 2020 Apr 9;63(7):3577-3595. [2]. Hudson BD, Christiansen E, Murdoch H, Jenkins L, Hansen AH, Madsen O, Ulven T, Milligan G. Complex pharmacology of novel allosteric free fatty acid 3 receptor ligands. Mol Pharmacol. 2014 Aug;86(2):200-10.

Molecular Formula	C₂₂H₂₂N₂O₃
Molecular Weight	362.42
InChIKey	HIWQJAGWEWRIIP-UHFFFAOYSA-N
SMILES	CC1=C(C(=O)Nc2ccccc2C)C(c2ccco2)C2=C(CCCC2=O)N1

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