41552-95-8

41552-95-8 structure

Name: A2AR-agonist-1
Chemical Name: N6-[(1H-indole-3-yl)ethyl]adenosine
CAS Number: 41552-95-8
Molecular Formula: C₂₀H₂₂N₆O₄
Molecular Weight: 410.42600
Catalog: Signaling Pathways GPCR/G Protein Adenosine Receptor
Create Date: 2018-06-15 11:44:50
Modify Date: 2024-01-10 08:30:33
A2AR-agonist-1 is a potent A2AR and ENT1 agonist with Ki of 4.39 and 3.47 for A2AR and ENT1.IC50 value: 4.39 and 3.47 (Ki) [1]Target: A2AR and ENT1A2AR-agonist-1 is a novel dual-action compound, targeting the Adenosine A2A Receptor and Adenosine Transporter for Neuroprotection.[1]

Name	N6-[(1H-indole-3-yl)ethyl]adenosine
Synonyms	N6-(4-hydroxybenzyl)adenosine N6-(2-(3-indolyl)ethyl)adenosine N6-[2-(indol-3-yl)ethyl]adenosine (2R,3S,4R,5R)-2-Hydroxymethyl-5-{6-[2-(1H-indol-3-yl)-ethylamino]-purin-9-yl}-tetrahydro-furan-3,4-diol 6-[2-(3-Indolyl)ethylamino]-9-(β-D-ribofuranosyl)purine N6-(2-indol-3-yl-ethyl)-adenosine A2AR-agonist-1

Description	A2AR-agonist-1 is a potent A2AR and ENT1 agonist with Ki of 4.39 and 3.47 for A2AR and ENT1.IC50 value: 4.39 and 3.47 (Ki) [1]Target: A2AR and ENT1A2AR-agonist-1 is a novel dual-action compound, targeting the Adenosine A2A Receptor and Adenosine Transporter for Neuroprotection.[1]
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Adenosine Receptor Research Areas >> Neurological Disease
References	[1]. Chen JB, et al. Design and synthesis of novel dual-action compounds targeting the adenosine A(2A) receptor and adenosine transporter for neuroprotection. ChemMedChem. 2011 Aug 1;6(8):1390-1400. [2]. Lin Yun-Lian, et al. Dual-action compounds targeting adenosine A2A receptor and adenosine transporter for prevention and treatment of neurodegenerative diseases. From PCT Int. Appl. (2012), WO 2012064340 A1 20120518. [3]. Chen, Chih-Cheng, et al. Methods and compositions for treating pain. From PCT Int. Appl. (2013), WO 2013120078 A1 20130815.