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2738486-70-7

2738486-70-7 structure

2738486-70-7 structure

Name: TREM2 agonist-1
Chemical Name: TREM2 agonist-1
CAS Number: 2738486-70-7
Molecular Formula: C₂₃H₂₁ClFN₅O
Molecular Weight: 437.90
Catalog: Research Areas Neurological Disease
Create Date: 2022-10-12 11:03:11
Modify Date: 2025-08-26 12:44:27
TREM2 agonist-1 (I-246) is a triggering receptor expressed on myeloid cells 2 (TREM2) agonist (EC50 between 3.0 μM and 100 μM)[1].

Name	TREM2 agonist-1

Description	TREM2 agonist-1 (I-246) is a triggering receptor expressed on myeloid cells 2 (TREM2) agonist (EC50 between 3.0 μM and 100 μM)[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
In Vitro	TREM2 agonist-1 (0-100 μM; 16 h) treatment activates hTREM2 in HEK293 cell[1]. Cell Viability Assay[1] Cell Line: HEK293 cells Concentration: 0-100 μM Incubation Time: 16 hours Result: Showed an EC50 value between 3.0 μM and 100 μM.
References	[1]. Lara C. CZABANIUK, et al. Heterocyclic compounds as triggering receptor expressed on myeloid cells 2 agonists and methods of use. WO2021226629A1.

Molecular Formula	C₂₃H₂₁ClFN₅O
Molecular Weight	437.90

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