VU 6008667

Modify Date: 2025-08-24 17:05:08

VU 6008667 Structure
VU 6008667 structure
Common Name VU 6008667
CAS Number 2092923-21-0 Molecular Weight 438.85
Density N/A Boiling Point N/A
Molecular Formula C24H17ClF2N2O2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of VU 6008667


VU 6008667 is a selective negative allosteric modulator of muscarinic acetylcholine receptor subtype 5 (M5 NAM) with IC50s of 1.2 μM and 1.6 μM for human M5 and rat M5, respectively. VU 6008667 has high CNS penetration[1].

 Names

Name VU 6008667

 VU 6008667 Biological Activity

Description VU 6008667 is a selective negative allosteric modulator of muscarinic acetylcholine receptor subtype 5 (M5 NAM) with IC50s of 1.2 μM and 1.6 μM for human M5 and rat M5, respectively. VU 6008667 has high CNS penetration[1].
Related Catalog
References

[1]. McGowan KM et al, Continued optimization of the M5 NAM ML375: Discovery of VU6008667, an M5 NAM with high CNS penetration and a desired short half-life in rat for addiction studies. Bioorg Med Chem Lett. 2017 Mar 15;27(6):1356-1359.

 Chemical & Physical Properties

Molecular Formula C24H17ClF2N2O2
Molecular Weight 438.85
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