VU 6008667

Names

[ CAS No. ]:
2092923-21-0

[ Name ]:
VU 6008667

Biological Activity

[Description]:

VU 6008667 is a selective negative allosteric modulator of muscarinic acetylcholine receptor subtype 5 (M5 NAM) with IC50s of 1.2 μM and 1.6 μM for human M5 and rat M5, respectively. VU 6008667 has high CNS penetration[1].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> mAChR

Signaling Pathways >> GPCR/G Protein >> mAChR

Research Areas >> Neurological Disease

[References]

[1]. McGowan KM et al, Continued optimization of the M5 NAM ML375: Discovery of VU6008667, an M5 NAM with high CNS penetration and a desired short half-life in rat for addiction studies. Bioorg Med Chem Lett. 2017 Mar 15;27(6):1356-1359.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₄H₁₇ClF₂N₂O₂

[ Molecular Weight ]:
438.85

Related Compounds

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