EGFR-IN-55

Modify Date: 2025-08-25 01:21:08

EGFR-IN-55 structure	Common Name	EGFR-IN-55
	CAS Number	2057423-46-6	Molecular Weight	526.42
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₅H₂₅Cl₂N₇O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of EGFR-IN-55

EGFR-IN-55 (Compound 8a) is a potent EGFR inhibitor with IC50 values of 70 nM and 3.9 nM against EGFRWT and EGFRL858R/T790M, respectively. EGFR-IN-55 arrests NCI-H1975 cells in G0/G1 phase and shows anticancer activity[1].

Name	EGFR-IN-55

Description	EGFR-IN-55 (Compound 8a) is a potent EGFR inhibitor with IC50 values of 70 nM and 3.9 nM against EGFRWT and EGFRL858R/T790M, respectively. EGFR-IN-55 arrests NCI-H1975 cells in G0/G1 phase and shows anticancer activity[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> JAK/STAT Signaling >> EGFR Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR
Target	EGFRL858R/T790M:3.9 nM (IC50) EGFRWT:70 nM (IC50)
References	[1]. Shao J, et al. Design, synthesis and SAR study of 2-aminopyrimidines with diverse Michael addition acceptors for chemically tuning the potency against EGFRL858R/T790M. Bioorg Med Chem. 2020 Oct 1;28(19):115680.

Molecular Formula	C₂₅H₂₅Cl₂N₇O₂
Molecular Weight	526.42

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EGFR-IN-55

Use of EGFR-IN-55

Names

EGFR-IN-55 Biological Activity

Chemical & Physical Properties

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.