(Rac)-5-Hydroxymethyl Tolterodine

Modify Date: 2024-01-06 14:39:13

(Rac)-5-Hydroxymethyl Tolterodine structure	Common Name	(Rac)-5-Hydroxymethyl Tolterodine
	CAS Number	200801-70-3	Molecular Weight	341.49
	Density	1.1±0.1 g/cm3	Boiling Point	490.7±45.0 °C at 760 mmHg
	Molecular Formula	C₂₂H₃₁NO₂	Melting Point	N/A
	MSDS	N/A	Flash Point	233.2±27.4 °C

Use of (Rac)-5-Hydroxymethyl Tolterodine

(Rac)-5-Hydroxymethyl Tolterodine ((Rac)-Desfesoterodine), an active metabolite of Tolterodine, is a mAChR antagonist (Ki values of 2.3 nM, 2 nM, 2.5 nM, 2.8 nM, and 2.9 nM for M1, M2, M3, M4, and M5 receptors, respectively). (Rac)-5-Hydroxymethyl Tolterodine can be used for overactive bladder research[1].

Name	2-[3-[di(propan-2-yl)amino]-1-phenylpropyl]-4-(hydroxymethyl)phenol
Synonym	More Synonyms

Description	(Rac)-5-Hydroxymethyl Tolterodine ((Rac)-Desfesoterodine), an active metabolite of Tolterodine, is a mAChR antagonist (Ki values of 2.3 nM, 2 nM, 2.5 nM, 2.8 nM, and 2.9 nM for M1, M2, M3, M4, and M5 receptors, respectively). (Rac)-5-Hydroxymethyl Tolterodine can be used for overactive bladder research[1].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> mAChR Signaling Pathways >> GPCR/G Protein >> mAChR Research Areas >> Neurological Disease
Target	Ki: M1 (2.3 nM), M2 (2 nM), M3 (2.5 nM), M4 (2.8 nM), and M5 (2.9 nM)[1]
In Vitro	In vitro, (Rac)-5-Hydroxymethyl Tolterodine (PNU-200577) produces a competitive and concentration-dependent inhibition of carbachol-induced contraction of guinea-pig isolated urinary bladder strips (KB of 0.84 nM; pA2 of 9.14)[2].
In Vivo	(Rac)-5-Hydroxymethyl Tolterodine (5-HMT; 0.88 μmol/kg; i.v.) treatment shows the binding activity of (Rac)-5-Hydroxymethyl Tolterodine to muscarinic receptors is significantly observed in all tissues, except cerebral cortex, with a longer duration in bladder[3].
References	[1]. L Nilvebrant, et al. Antimuscarinic potency and bladder selectivity of PNU-200577, a major metabolite of tolterodine. Pharmacol Toxicol. 1997 Oct;81(4):169-72. [2]. B Malhotra, et al. The design and development of fesoterodine as a prodrug of 5-hydroxymethyl tolterodine (5-HMT), the active metabolite of tolterodine. Curr Med Chem. 2009;16(33):4481-9. [3]. Shizuo Yamada, et al. Muscarinic receptor binding of fesoterodine, 5-hydroxymethyl tolterodine, and tolterodine in rat tissues after the oral, intravenous, or intravesical administration. J Pharmacol Sci. 2019 May;140(1):73-78.

Density	1.1±0.1 g/cm3
Boiling Point	490.7±45.0 °C at 760 mmHg
Molecular Formula	C₂₂H₃₁NO₂
Molecular Weight	341.49
Flash Point	233.2±27.4 °C
Exact Mass	341.235474
PSA	43.70000
LogP	4.12
Vapour Pressure	0.0±1.3 mmHg at 25°C
Index of Refraction	1.563

Hazard Codes	Xi
HS Code	2922509090

Precursor 9
CAS#:250214-39-2 (+)-N,N-diisopr... CAS#:14371-10-9 Cinnamic aldehyde CAS#:623-05-2 4-Hydroxybenzyl... CAS#:156755-23-6 6-Bromo-4-pheny...
CAS#:250214-37-0 Benzenepropanol... CAS#:108-18-9 Diisopropylamine CAS#:99-76-3 Methyl 4-hydrox... CAS#:380636-44-2 2-Hydroxy-4-phe...
CAS#:2687-12-9 (3-Chloro-1-pro...
DownStream 2
CAS#:207679-81-0 5-hydroxymethyl... CAS#:286930-02-7 Fesoterodine

HS Code	2922509090
Summary	2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Benzenemethanol, 3-[3-[bis(1-methylethyl)amino]-1-phenylpropyl]-4-hydroxy-

N,N-diisopropyl-3-(2-hydroxy-5-hydroxymethylphenyl)-3-phenylpropylamine

RS-N,N-diisopropyl-3-(2-hydroxy-5-(hydroxymethyl)phenyl)-3-phenylpropylamine

2-(3-diisopropylamino-1-phenylpropyl)-4-hydroxymethylphenol

2-[3-(Diisopropylamino)-1-phenylpropyl]-4-(hydroxymethyl)phenol

rac 5-Hydroxymethyl Tolterodine

feso deacyl raceme

(R)-2-[3-(diisopropylamino)-1-phenylpropyl]-4-(hydroxymethyl)phenol

3-[3-[Bis(1-methylethyl)amino]-1-phenylpropyl]-4-hydroxybenzenemethanol

Fesoterodine fumarate Intermediate 1

DC Chemicals Limited
China
Product Name: (Rac)-5-Hydroxymethyl Tolterodine
Price: $Inquiry/1g
Purity: 98.0%
Stocking Period: 1 Day
Contact: Tony Cao

Get all suppliers and price by the below link:

(Rac)-5-Hydroxymethyl Tolterodine suppliers

Price: ￥2000/5 mg

Reference only. check more (Rac)-5-Hydroxymethyl Tolterodine price

(Rac)-5-Hydroxymethyl Tolterodine

Use of (Rac)-5-Hydroxymethyl Tolterodine

Names

(Rac)-5-Hydroxymethyl Tolterodine Biological Activity

Chemical & Physical Properties

Safety Information

Synthetic Route

Precursor & DownStream

Customs

Synonyms