250214-40-5
250214-40-5 structure
- Name: (Rac)-5-Hydroxymethyl Tolterodine hydrochloride
- Chemical Name: (Rac)-5-Hydroxymethyl Tolterodine hydrochloride
- CAS Number: 250214-40-5
- Molecular Formula: C22H32ClNO2
- Molecular Weight: 377.95
- Catalog: Signaling Pathways GPCR/G Protein mAChR
- Create Date: 2021-12-19 17:23:48
- Modify Date: 2024-02-04 07:53:06
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(Rac)-5-Hydroxymethyl Tolterodine ((Rac)-Desfesoterodine) hydrochloride, an active metabolite of Tolterodine, is a mAChR antagonist (Ki values of 2.3 nM, 2 nM, 2.5 nM, 2.8 nM, and 2.9 nM for M1, M2, M3, M4, and M5 receptors, respectively). (Rac)-5-Hydroxymethyl Tolterodine hydrochloride can be used for overactive bladder research[1].
| Name | (Rac)-5-Hydroxymethyl Tolterodine hydrochloride |
|---|
| Description | (Rac)-5-Hydroxymethyl Tolterodine ((Rac)-Desfesoterodine) hydrochloride, an active metabolite of Tolterodine, is a mAChR antagonist (Ki values of 2.3 nM, 2 nM, 2.5 nM, 2.8 nM, and 2.9 nM for M1, M2, M3, M4, and M5 receptors, respectively). (Rac)-5-Hydroxymethyl Tolterodine hydrochloride can be used for overactive bladder research[1]. |
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| Related Catalog | |
| Target |
Ki: M1 (2.3 nM), M2 (2 nM), M3 (2.5 nM), M4 (2.8 nM), and M5 (2.9 nM)[1] |
| In Vitro | In vitro, (Rac)-5-Hydroxymethyl Tolterodine (PNU-200577) hydrochloride produces a competitive and concentration-dependent inhibition of carbachol-induced contraction of guinea-pig isolated urinary bladder strips (KB of 0.84 nM; pA2 of 9.14)[2]. |
| In Vivo | (Rac)-5-Hydroxymethyl Tolterodine (5-HMT; 0.88 μmol/kg; i.v.) hydrochloride treatment shows the binding activity of (Rac)-5-Hydroxymethyl Tolterodine hydrochloride to muscarinic receptors is significantly observed in all tissues, except cerebral cortex, with a longer duration in bladder[3]. |
| References |
| Molecular Formula | C22H32ClNO2 |
|---|---|
| Molecular Weight | 377.95 |