2-chloroadenine

Modify Date: 2024-01-03 01:09:33

2-chloroadenine Structure
2-chloroadenine structure
Common Name 2-chloroadenine
CAS Number 1839-18-5 Molecular Weight 169.57
Density 1.8±0.1 g/cm3 Boiling Point 485.5±27.0 °C at 760 mmHg
Molecular Formula C5H4ClN5 Melting Point >300°C(dec)
MSDS USA Flash Point 247.4±23.7 °C
Symbol GHS07
GHS07
Signal Word Warning

 Use of 2-chloroadenine


2-Chloroadenine (6-Amino-2-chloropurine) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

 Names

Name 2-Chloroadenine
Synonym More Synonyms

 2-chloroadenine Biological Activity

Description 2-Chloroadenine (6-Amino-2-chloropurine) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
Related Catalog
In Vitro 2-Chloroadenine 是一种杂环构建块,已被用于合成具有抗肿瘤活性的腺苷抗代谢产物。它也是 2-氯-2'-脱氧腺苷的主要分解产物。
References

[1]. Bauta, WE, Schulmeier, BE, Bur the , BJ, et al.A new process for antineoplastic agent clofarabineOrg. Proc. Res. Dev.8(6)889-896(2004)

[2]. Bontemps, F., Delacauw, A., Cardoen, S., et al. Metabolism and cytotoxic effects of 2-chloroadenine, the major catabolite of 2-chloro-29-deoxyadenosine Biochem. Pharmacol.59(10)1237-1243(2000)

 Chemical & Physical Properties

Density 1.8±0.1 g/cm3
Boiling Point 485.5±27.0 °C at 760 mmHg
Melting Point >300°C(dec)
Molecular Formula C5H4ClN5
Molecular Weight 169.57
Flash Point 247.4±23.7 °C
Exact Mass 169.015518
PSA 80.48000
LogP 0.35
Vapour Pressure 0.0±1.2 mmHg at 25°C
Index of Refraction 1.827
Storage condition -20°C Freezer

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302
Precautionary Statements P301 + P312 + P330
Hazard Codes Xi
Risk Phrases 22
RIDADR NONH for all modes of transport
HS Code 2933990090

 Customs

HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Articles14

More Articles
Cytotoxicity and pharmacokinetics of cladribine metabolite, 2-chloroadenine in patients with leukemia.

Cancer Lett. 210(2) , 171-7, (2004)

The nucleoside analog 2-chlorodeoxyadenosine (Cladribine, CdA) is used in the treatment of patients with several hematological malignancies. After administration of CdA, the major catabolite measured ...

[Synthesis of 2-chloro-2'-deoxyadenosine by microbiological transglycosylation using a recombinant Escherichia coli strain].

Prikl. Biokhim. Mikrobiol. 44(2) , 181-6, (2008)

Cladribine (2-chloro-2'-deoxyadenosine) was synthesized using intact cells of the recombinant Escherichia coli strain producing Geobacillus stearothermophilus B-2194 thermostable purine-nucleoside pho...

Age-related changes in ischemic tolerance in male and female mouse hearts.

J. Mol. Cell. Cardiol. 38(2) , 245-56, (2005)

Aging is associated with reduced tolerance to ischemic insult, and genesis of this intolerant phenotype is poorly understood. We characterized effects of aging and gender on cardiovascular function an...

 Synonyms

CHLOROADENINE
2-chlor-9h-purin-6-amin
7H-Purin-6-amine, 2-chloro-
6-amino-2-chloro-9H-purine
2-chloro-7h-purin-6-amine
6-amino-2-chloropurine
6-Amino-2-chloro-7H-purine
MFCD00127773
2-Chloro-1H-purin-6-amine
2-Chloroadenine
2-CHLORO-6-AMINOPURINE
9H-purin-6-amine, 2-chloro-
2-chloropurin-6-amine
2-Chlorophenthiazine
2-chloro-9H-purin-6-amine
Purine, 6-amino-2-chloro-
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