2-chloroadenine

Names

[ Name ]:
2-chloroadenine

[Synonym ]:
CHLOROADENINE
2-chlor-9h-purin-6-amin
7H-Purin-6-amine, 2-chloro-
6-amino-2-chloro-9H-purine
2-chloro-7h-purin-6-amine
6-amino-2-chloropurine
6-Amino-2-chloro-7H-purine
MFCD00127773
2-Chloro-1H-purin-6-amine
2-Chloroadenine
2-CHLORO-6-AMINOPURINE
9H-purin-6-amine, 2-chloro-
2-chloropurin-6-amine
2-Chlorophenthiazine
2-chloro-9H-purin-6-amine
Purine, 6-amino-2-chloro-

Biological Activity

[Description]:

2-Chloroadenine (6-Amino-2-chloropurine) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[In Vitro]

2-Chloroadenine 是一种杂环构建块，已被用于合成具有抗肿瘤活性的腺苷抗代谢产物。它也是 2-氯-2'-脱氧腺苷的主要分解产物。

[References]

[1]. Bauta, WE, Schulmeier, BE, Bur the , BJ, et al.A new process for antineoplastic agent clofarabineOrg. Proc. Res. Dev.8(6)889-896(2004)

[2]. Bontemps, F., Delacauw, A., Cardoen, S., et al. Metabolism and cytotoxic effects of 2-chloroadenine, the major catabolite of 2-chloro-29-deoxyadenosine Biochem. Pharmacol.59(10)1237-1243(2000)

Chemical & Physical Properties

[ Density]:
1.8±0.1 g/cm3

[ Boiling Point ]:
485.5±27.0 °C at 760 mmHg

[ Melting Point ]:
>300°C(dec)

[ Molecular Formula ]:
C₅H₄ClN₅

[ Molecular Weight ]:
169.57

[ Flash Point ]:
247.4±23.7 °C

[ Exact Mass ]:
169.015518

[ PSA ]:
80.48000

[ LogP ]:
0.35

[ Vapour Pressure ]:
0.0±1.2 mmHg at 25°C

[ Index of Refraction ]:
1.827

[ Storage condition ]:
-20°C Freezer

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302

[ Precautionary Statements ]:
P301 + P312 + P330

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
22

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2933990090

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Cytotoxicity and pharmacokinetics of cladribine metabolite, 2-chloroadenine in patients with leukemia.

Cancer Lett. 210(2) , 171-7, (2004)

The nucleoside analog 2-chlorodeoxyadenosine (Cladribine, CdA) is used in the treatment of patients with several hematological malignancies. After administration of CdA, the major catabolite measured ...

[Synthesis of 2-chloro-2'-deoxyadenosine by microbiological transglycosylation using a recombinant Escherichia coli strain].

Prikl. Biokhim. Mikrobiol. 44(2) , 181-6, (2008)

Cladribine (2-chloro-2'-deoxyadenosine) was synthesized using intact cells of the recombinant Escherichia coli strain producing Geobacillus stearothermophilus B-2194 thermostable purine-nucleoside pho...

Age-related changes in ischemic tolerance in male and female mouse hearts.

J. Mol. Cell. Cardiol. 38(2) , 245-56, (2005)

Aging is associated with reduced tolerance to ischemic insult, and genesis of this intolerant phenotype is poorly understood. We characterized effects of aging and gender on cardiovascular function an...

Related Compounds

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