spongosine

Names

[ Name ]:
spongosine

[Synonym ]:
9H-purin-6-amine
2-Methoxy-adenosin
2-methoxy-adenosine
Spongosine

Biological Activity

[Description]:

Spongosine (2-Methoxyadenosine) is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

[References]

[1]. Man S, et al. Potential and promising anticancer drugs from adenosine and its analogs. Drug Discov Today. 2021 Jun;26(6):1490-1500.

[2]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

Chemical & Physical Properties

[ Density]:
1.98g/cm3

[ Boiling Point ]:
705ºC at 760mmHg

[ Molecular Formula ]:
C₁₁H₁₅N₅O₅

[ Molecular Weight ]:
297.27

[ Flash Point ]:
380.2ºC

[ Exact Mass ]:
297.10700

[ PSA ]:
148.77000

[ Vapour Pressure ]:
7.3E-21mmHg at 25°C

[ Index of Refraction ]:
1.829

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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