Nav1.7-IN-3
Modify Date: 2025-09-28 16:02:10
Nav1.7-IN-3 structure
|
Common Name | Nav1.7-IN-3 | ||
|---|---|---|---|---|
| CAS Number | 1788872-06-9 | Molecular Weight | 430.95 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C17H20ClFN4O2S2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Nav1.7-IN-3Nav1.7-IN-3 is a selective, orally bioavailable voltage-gated sodium channel Nav1.7 inhibitor with an IC50 of 8 nM. Pain relief. Limited CNS penetration[1]. |
| Name | Nav1.7-IN-3 |
|---|
| Description | Nav1.7-IN-3 is a selective, orally bioavailable voltage-gated sodium channel Nav1.7 inhibitor with an IC50 of 8 nM. Pain relief. Limited CNS penetration[1]. |
|---|---|
| Related Catalog | |
| Target |
IC50: 8 nM (Nav1.7)[1] |
| In Vivo | Nav1.7-IN-3 (compound 5) shows excellent potency, selectivity, behavioral efficacy in a rodent pain model (30 mg/kg, oral, 35 minutes), and efficacy in a mouse itch model (30 mg/kg, oral, 30 minutes)[1]. Animal Model: C57BL/6 male mice (n=8/group, 25-30g) Dosage: 1, 3, and 10 mg/kg Administration: Oral (0-35 mintues) Result: Nav1.7-IN-3 demonstrates statistically significant, dose-dependent reversal of these effects in the acute phase of the experiment (0-5 min period post formalin injection) and the tonic phase of the experiment (20-35 min period post formalin injection) with full reversal of formalin effects in the tonic phase[1] |
| References |
| Molecular Formula | C17H20ClFN4O2S2 |
|---|---|
| Molecular Weight | 430.95 |