HO-PEG13-OH

Modify Date: 2024-01-09 17:58:19

HO-PEG13-OH Structure
HO-PEG13-OH structure
Common Name HO-PEG13-OH
CAS Number 17598-96-8 Molecular Weight 590.69900
Density 1.116g/cm3 Boiling Point 631.6ºC at 760mmHg
Molecular Formula C26H54O14 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of HO-PEG13-OH


HO-PEG13-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name 2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol
Synonym More Synonyms

 HO-PEG13-OH Biological Activity

Description HO-PEG13-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Density 1.116g/cm3
Boiling Point 631.6ºC at 760mmHg
Molecular Formula C26H54O14
Molecular Weight 590.69900
Exact Mass 590.35100
PSA 151.22000
Vapour Pressure 1.32E-18mmHg at 25°C
Index of Refraction 1.465

 Safety Information

HS Code 2909499000

 Synthetic Route

~77%

HO-PEG13-OH Structure

HO-PEG13-OH

CAS#:17598-96-8

Literature: Andrus, Merritt B.; Turner, Timothy M.; Updegraff, Emily P.; Sauna, Zuben E.; Ambudkar, Suresh V. Tetrahedron Letters, 2001 , vol. 42, # 23 p. 3819 - 3822

~%

HO-PEG13-OH Structure

HO-PEG13-OH

CAS#:17598-96-8

Literature: Jayasuriya, Nimal; Bosak, Stanislav; Regen, Steven L. Journal of the American Chemical Society, 1990 , vol. 112, # 15 p. 5851 - 5854

~%

HO-PEG13-OH Structure

HO-PEG13-OH

CAS#:17598-96-8

Literature: Jayasuriya, Nimal; Bosak, Stanislav; Regen, Steven L. Journal of the American Chemical Society, 1990 , vol. 112, # 15 p. 5851 - 5854

~%

HO-PEG13-OH Structure

HO-PEG13-OH

CAS#:17598-96-8

Literature: Andrus, Merritt B.; Turner, Timothy M.; Updegraff, Emily P.; Sauna, Zuben E.; Ambudkar, Suresh V. Tetrahedron Letters, 2001 , vol. 42, # 23 p. 3819 - 3822

~%

HO-PEG13-OH Structure

HO-PEG13-OH

CAS#:17598-96-8

Literature: Andrus, Merritt B.; Turner, Timothy M.; Updegraff, Emily P.; Sauna, Zuben E.; Ambudkar, Suresh V. Tetrahedron Letters, 2001 , vol. 42, # 23 p. 3819 - 3822

~%

HO-PEG13-OH Structure

HO-PEG13-OH

CAS#:17598-96-8

Literature: Andrus, Merritt B.; Turner, Timothy M.; Updegraff, Emily P.; Sauna, Zuben E.; Ambudkar, Suresh V. Tetrahedron Letters, 2001 , vol. 42, # 23 p. 3819 - 3822

~%

HO-PEG13-OH Structure

HO-PEG13-OH

CAS#:17598-96-8

Literature: Andrus, Merritt B.; Turner, Timothy M.; Updegraff, Emily P.; Sauna, Zuben E.; Ambudkar, Suresh V. Tetrahedron Letters, 2001 , vol. 42, # 23 p. 3819 - 3822

 Customs

HS Code 2909499000
Summary 2909499000. ether-alcohols and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:5.5%. General tariff:30.0%

 Synonyms

3,6,9,12,15,18,21,24,27,30,33,36-Dodecaoxaoctatriacontane-1,38-diol
tridecaethylene glycol
EINECS 241-569-7