Supramolecular surfactants: polymerized bolaphiles exhibiting extraordinarily high membrane-disrupting activity

N Jayasuriya, S Bosak, SL Regen

Index: Jayasuriya, Nimal; Bosak, Stanislav; Regen, Steven L. Journal of the American Chemical Society, 1990 , vol. 112, # 15 p. 5851 - 5854

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Citation Number: 27

Abstract

Abstract: Polymerized forms of saturated, olefinic, and acetylenic bolaphiles (double-headed surfactants) have been prepared by condensation of a series of a, w-dicarboxylic acids with tridecaethylene glycol, and evaluated for their ability to induce the release of 5 (6)- carboxyfluorescein (CF) entrapped within large unilamellar vesicles derived from 1-palmitoyl- 2-oleoyl-sn-glycero-3-phosphocholine (POPC). Each amphiphilic polymer was found to ...