Donitriptan monohydrochloride
Donitriptan monohydrochloride structure
|
Common Name | Donitriptan monohydrochloride | ||
|---|---|---|---|---|
| CAS Number | 170911-68-9 | Molecular Weight | 439.94 | |
| Density | N/A | Boiling Point | 727.1ºC at 760 mmHg | |
| Molecular Formula | C23H26ClN5O2 | Melting Point | N/A | |
| MSDS | USA | Flash Point | 393.6ºC | |
| Symbol |
GHS06 |
Signal Word | Danger | |
Use of Donitriptan monohydrochlorideDonitriptan hydrochloride (F-11356) is a potent, high efficacy agonist at 5-HT1B/1D receptors with pKis of 9.4 and 9.3, respectively[1]. |
| Name | 4-[4-[2-[[3-(2-aminoethyl)-1H-indol-5-yl]oxy]acetyl]piperazin-1-yl]benzonitrile,hydrochloride |
|---|---|
| Synonym | More Synonyms |
| Description | Donitriptan hydrochloride (F-11356) is a potent, high efficacy agonist at 5-HT1B/1D receptors with pKis of 9.4 and 9.3, respectively[1]. |
|---|---|
| Related Catalog | |
| Target |
5-HT1B Receptor:9.4 (pKi) 5-HT1D Receptor:9.3 (pKi) |
| References |
| Boiling Point | 727.1ºC at 760 mmHg |
|---|---|
| Molecular Formula | C23H26ClN5O2 |
| Molecular Weight | 439.94 |
| Flash Point | 393.6ºC |
| Exact Mass | 439.17800 |
| PSA | 98.38000 |
| LogP | 3.77358 |
| Vapour Pressure | 5.34E-21mmHg at 25°C |
| Storage condition | 2-8°C |
| Symbol |
GHS06 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H301-H312-H315-H319-H332-H335 |
| Precautionary Statements | P261-P280-P301 + P310-P305 + P351 + P338 |
| RIDADR | UN 3439 6.1 / PGIII |
|
Donitriptan, but not sumatriptan, inhibits capsaicin-induced canine external carotid vasodilatation via 5-HT1B rather than 5-HT1D receptors.
Br. J. Pharmacol. 149(1) , 82-91, (2006) It has been suggested that during a migraine attack capsaicin-sensitive trigeminal sensory nerves release calcitonin gene-related peptide (CGRP), resulting in cranial vasodilatation and central nocice... |
|
|
Donitriptan (Pierre Fabre).
Curr. Opin. Investig. Drugs 2(3) , 415-8, (2001) Pierre Fabre is developing donitriptan, a piperazide 5-HT1D agonist, as a potential treatment for migraine [175854]. In January 2001, donitriptan had completed phase I trials for migraine and was sche... |
|
|
Effects of donitriptan on carotid haemodynamics and cardiac output distribution in anaesthetized pigs.
Cephalalgia 22(1) , 37-47, (2002) We investigated the effects of donitriptan, which possesses a uniquely high affinity and efficacy at 5-HT1B/1D receptors, on carotid and systemic haemodynamics in anaes thetized pigs. Donitriptan (0.1... |
| Donitriptan hydrochloride |
| Donitriptan monohydrochloride |
| Nafadotride |