170912-52-4

170912-52-4 structure

Name: Donitriptan
Chemical Name: 4-[4-[2-[[3-(2-aminoethyl)-1H-indol-5-yl]oxy]acetyl]piperazin-1-yl]benzonitrile
CAS Number: 170912-52-4
Molecular Formula: C₂₃H₂₅N₅O₂
Molecular Weight: 403.47700
Catalog: Signaling Pathways GPCR/G Protein 5-HT Receptor
Create Date: 2019-02-04 16:42:38
Modify Date: 2024-02-07 19:04:56
Donitriptan is a potent, high efficacy agonist at 5-HT1B/1D receptors with pKis of 9.4 and 9.3, respectively[1].

Name	4-[4-[2-[[3-(2-aminoethyl)-1H-indol-5-yl]oxy]acetyl]piperazin-1-yl]benzonitrile
Synonyms	Donitriptan

Description	Donitriptan is a potent, high efficacy agonist at 5-HT1B/1D receptors with pKis of 9.4 and 9.3, respectively[1].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor
Target	5-HT1B Receptor:9.4 (pKi) 5-HT1D Receptor:9.3 (pKi)
References	[1]. Muñoz-Islas E, et al. Donitriptan, but not sumatriptan, inhibits capsaicin-induced canine external carotid vasodilatation via 5-HT1B rather than 5-HT1D receptors. Br J Pharmacol. 2006 Sep;149(1):82-91.