Foliglurax monohydrochloride

Modify Date: 2024-01-10 20:07:01

Foliglurax monohydrochloride Structure
Foliglurax monohydrochloride structure
Common Name Foliglurax monohydrochloride
CAS Number 2133294-96-7 Molecular Weight 457.97
Density N/A Boiling Point N/A
Molecular Formula C23H24ClN3O3S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Foliglurax monohydrochloride


Foliglurax monohydrochloride (PXT002331 monohydrochloride) is a highly selective and potent, brain-penetrant mGluR4 positive allosteric modulator (PAM) with an EC50 of 79±19 nM[1]. Antiparkinsonian effect[1].

 Names

Name Foliglurax monohydrochloride

 Foliglurax monohydrochloride Biological Activity

Description Foliglurax monohydrochloride (PXT002331 monohydrochloride) is a highly selective and potent, brain-penetrant mGluR4 positive allosteric modulator (PAM) with an EC50 of 79±19 nM[1]. Antiparkinsonian effect[1].
Related Catalog
Target

mGlu4:79 nM (EC50)

In Vitro Foliglurax, a highly selective and potent mGlu4 receptor PAM with a marked brain-penetrance feature, might revolutionize the field of mGlu4 receptor drug targeting in CNS disorders[2].
References

[1]. Charvin D, et al. Discovery, Structure-Activity Relationship, and Antiparkinsonian Effect of a Potent and Brain-Penetrant Chemical Series of Positive Allosteric Modulators of Metabotropic Glutamate Receptor 4. J Med Chem. 2017 Oct 26;60(20):8515-8537.

[2]. Volpi C, et al. Opportunities and challenges in drug discovery targeting metabotropic glutamate receptor 4. Expert Opin Drug Discov. 2018 May;13(5):411-423.

 Chemical & Physical Properties

Molecular Formula C23H24ClN3O3S
Molecular Weight 457.97
Storage condition 2-8℃
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Price: ¥4950/10 mM * 1 mL in DMSO

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