Foliglurax

Modify Date: 2024-01-10 11:48:31

Foliglurax structure	Common Name	Foliglurax
	CAS Number	1883329-51-8	Molecular Weight	421.51
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₃H₂₃N₃O₃S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Foliglurax

Foliglurax (PXT002331) is a highly selective and potent, brain-penetrant mGluR4 positive allosteric modulator (PAM) with an EC50 of 79 nM[1]. Antiparkinsonian effect[1].

Name	Foliglurax

Description	Foliglurax (PXT002331) is a highly selective and potent, brain-penetrant mGluR4 positive allosteric modulator (PAM) with an EC50 of 79 nM[1]. Antiparkinsonian effect[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> mGluR Research Areas >> Neurological Disease
Target	mGlu4:79 nM (EC50)
In Vitro	Foliglurax, a highly selective and potent mGlu4 receptor PAM with a marked brain-penetrance feature, might revolutionize the field of mGlu4 receptor drug targeting in CNS disorders[2].
References	[1]. Charvin D, et al. Discovery, Structure-Activity Relationship, and Antiparkinsonian Effect of a Potent and Brain-Penetrant Chemical Series of Positive Allosteric Modulators of Metabotropic Glutamate Receptor 4. J Med Chem. 2017 Oct 26;60(20):8515-8537. [2]. Volpi C, et al. Opportunities and challenges in drug discovery targeting metabotropic glutamate receptor 4. Expert Opin Drug Discov. 2018 May;13(5):411-423.

Molecular Formula	C₂₃H₂₃N₃O₃S
Molecular Weight	421.51
Storage condition	2-8°C

DC Chemicals Limited
China
Product Name: Foliglurax
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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