YAP-TEAD-IN-1
Modify Date: 2025-08-27 14:40:04
YAP-TEAD-IN-1 structure
|
Common Name | YAP-TEAD-IN-1 | ||
|---|---|---|---|---|
| CAS Number | 1659305-78-8 | Molecular Weight | 2019.86 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C93H144ClN23O21S2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of YAP-TEAD-IN-1YAP-TEAD-IN-1 is a potent and competitive inhibitor of YAP–TEAD interaction (IC50=25 nM). YAP-TEAD-IN-1 is a 17mer peptide and shows a higher the binding affinity to TEAD1 (Kd=15 nM) than YAP (50-171) (Kd=40 nM)[1]. |
| Name | YAP-TEAD-IN-1 |
|---|
| Description | YAP-TEAD-IN-1 is a potent and competitive inhibitor of YAP–TEAD interaction (IC50=25 nM). YAP-TEAD-IN-1 is a 17mer peptide and shows a higher the binding affinity to TEAD1 (Kd=15 nM) than YAP (50-171) (Kd=40 nM)[1]. |
|---|---|
| Related Catalog | |
| Target |
IC50: 25 nM (YAP–TEAD interaction)[1] |
| In Vitro | YAP-TEAD-IN-1 (peptide 17)(2 μM) is against endogenous YAP binding to GST-TEAD (1209-426) in a GST pull-down assay, the Kd of His-YAP1209-426 is determined to be 40 nM[1]. |
| References |
| Molecular Formula | C93H144ClN23O21S2 |
|---|---|
| Molecular Weight | 2019.86 |
| InChIKey | QRAZSFFSGBFSLJ-GUOWWYSESA-N |
| SMILES | CCCCC1NC(=O)C(CCCCN)NC(=O)C(CCCNC(=N)N)NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(Cc2cccc(Cl)c2)NC(=O)C2CCCN2C(=O)C(NC(C)=O)C(C)C)CCSSCC(C(=O)NC(CCCCN)C(=O)N2CCCC2C(=O)N2CCCC2C(=O)NC(CCC(=O)O)C(N)=O)NC(=O)C(Cc2ccccc2)NC(=O)C(CO)NC(=O)C(C)NC(=O)C2CCCN2C1=O |