1659305-78-8

1659305-78-8 structure

Name: YAP-TEAD-IN-1
Chemical Name: YAP-TEAD-IN-1
CAS Number: 1659305-78-8
Molecular Formula: C₉₃H₁₄₄ClN₂₃O₂₁S₂
Molecular Weight: 2019.86
Catalog: Signaling Pathways Stem Cell/Wnt YAP
Create Date: 2020-06-01 13:43:32
Modify Date: 2024-01-10 19:34:13
YAP-TEAD-IN-1 is a potent and competitive inhibitor of YAP–TEAD interaction (IC50=25 nM). YAP-TEAD-IN-1 is a 17mer peptide and shows a higher the binding affinity to TEAD1 (Kd=15 nM) than YAP (50-171) (Kd=40 nM)[1].

Name	YAP-TEAD-IN-1

Description	YAP-TEAD-IN-1 is a potent and competitive inhibitor of YAP–TEAD interaction (IC50=25 nM). YAP-TEAD-IN-1 is a 17mer peptide and shows a higher the binding affinity to TEAD1 (Kd=15 nM) than YAP (50-171) (Kd=40 nM)[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Stem Cell/Wnt >> YAP
Target	IC50: 25 nM (YAP–TEAD interaction)[1]
In Vitro	YAP-TEAD-IN-1 (peptide 17)(2 μM) is against endogenous YAP binding to GST-TEAD (1209-426) in a GST pull-down assay, the Kd of His-YAP1209-426 is determined to be 40 nM[1].
References	[1]. Zhang Z, et al. Structure-Based Design and Synthesis of Potent Cyclic Peptides Inhibiting the YAP-TEAD Protein-Protein Interaction.ACS Med Chem Lett. 2014 Jul 14;5(9):993-8.

Molecular Formula	C₉₃H₁₄₄ClN₂₃O₂₁S₂
Molecular Weight	2019.86