DC Chemicals Limited
China
Product Name: CDK6/9-IN-1
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

2414373-55-8

2414373-55-8 structure

2414373-55-8 structure

Name: CDK6/9-IN-1
Chemical Name: CDK6/9-IN-1
CAS Number: 2414373-55-8
Molecular Formula: C₂₂H₂₅ClN₈O
Molecular Weight: 452.94
Catalog: Signaling Pathways Cell Cycle/DNA Damage CDK
Create Date: 2020-06-01 16:47:22
Modify Date: 2024-01-09 14:29:35
CDK6/9-IN-1 (compound 66) is an oral available and dual CDK 6 and CDK 9 inhibitor, with IC50 values of 40.5 nM and 39.5 nM for CDK6 anmd CDK9, respectively[1].

Name	CDK6/9-IN-1

Description	CDK6/9-IN-1 (compound 66) is an oral available and dual CDK 6 and CDK 9 inhibitor, with IC50 values of 40.5 nM and 39.5 nM for CDK6 anmd CDK9, respectively[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> CDK
Target	CDK6:40.5 nM (IC50) CDK9:39.5 nM (IC50)
In Vitro	CDK6/9-IN-1 (compound 66, 4 or 8 μM in MDA-MB-231 cells) treatment induces G0/G1 cell cycle arrest (71.85% and 77.51%, respectively), when compared with the control (57.65%)[1].
In Vivo	CDK6/9-IN-1 (compound 66) significantly inhibits tumor growth in an xenograft mouse model with no obvious toxicity, indicating the promising therapeutic potential of CDK6/9 dual inhibitors for cancer treatment[1].
References	[1]. Yang Wang, et al. Discovery and SARs of 5-Chloro- N4-phenyl- N2-(pyridin-2-yl)pyrimidine-2,4-diamine Derivatives as Oral Available and Dual CDK 6 and 9 Inhibitors With Potent Antitumor Activity. J Med Chem. 2020 Mar 26;63(6):3327-3347.

Molecular Formula	C₂₂H₂₅ClN₈O
Molecular Weight	452.94