YAP-TEAD-IN-1 TFA

Modify Date: 2024-01-07 17:48:21

YAP-TEAD-IN-1 TFA Structure
YAP-TEAD-IN-1 TFA structure
Common Name YAP-TEAD-IN-1 TFA
CAS Number 1659305-79-9 Molecular Weight N/A
Density N/A Boiling Point N/A
Molecular Formula C93H144ClN23O21S2.xC2HF3O2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of YAP-TEAD-IN-1 TFA


YAP-TEAD-IN-1 TFA is a potent and competitive peptide inhibitor of YAP-TEAD interaction (IC50=25 nM). YAP-TEAD-IN-1 TFA is a 17mer peptide and shows a higher the binding affinity to TEAD1 (Kd=15 nM) than YAP (50-171) (Kd= 40 nM)[1].

 Names

Name YAP-TEAD-IN-1 TFA

 YAP-TEAD-IN-1 TFA Biological Activity

Description YAP-TEAD-IN-1 TFA is a potent and competitive peptide inhibitor of YAP-TEAD interaction (IC50=25 nM). YAP-TEAD-IN-1 TFA is a 17mer peptide and shows a higher the binding affinity to TEAD1 (Kd=15 nM) than YAP (50-171) (Kd= 40 nM)[1].
Related Catalog
Target

IC50: 25 nM (YAP-TEAD interaction)[1]

In Vitro YAP-TEAD-IN-1 (peptide 17)(2 μM) is against endogenous YAP binding to GST-TEAD(1209-426) in a GST pull-down assay, the Kd of His-YAP(1209-426) is determined to be 40 nM[1].
References

[1]. Zhang Z, et al. Structure-Based Design and Synthesis of Potent Cyclic Peptides Inhibiting the YAP-TEAD Protein-Protein Interaction.ACS Med Chem Lett. 2014 Jul 14;5(9):993-8.

 Chemical & Physical Properties

Molecular Formula C93H144ClN23O21S2.xC2HF3O2
The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.