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YAP-TEAD-IN-1 TFA

Names

[ CAS No. ]:
1659305-79-9

[ Name ]:
YAP-TEAD-IN-1 TFA

Biological Activity

[Description]:

YAP-TEAD-IN-1 TFA is a potent and competitive peptide inhibitor of YAP-TEAD interaction (IC50=25 nM). YAP-TEAD-IN-1 TFA is a 17mer peptide and shows a higher the binding affinity to TEAD1 (Kd=15 nM) than YAP (50-171) (Kd= 40 nM)[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Stem Cell/Wnt >> YAP

[Target]

IC50: 25 nM (YAP-TEAD interaction)[1]


[In Vitro]

YAP-TEAD-IN-1 (peptide 17)(2 μM) is against endogenous YAP binding to GST-TEAD(1209-426) in a GST pull-down assay, the Kd of His-YAP(1209-426) is determined to be 40 nM[1].

[References]

[1]. Zhang Z, et al. Structure-Based Design and Synthesis of Potent Cyclic Peptides Inhibiting the YAP-TEAD Protein-Protein Interaction.ACS Med Chem Lett. 2014 Jul 14;5(9):993-8.

Chemical & Physical Properties

[ Molecular Formula ]:
C93H144ClN23O21S2.xC2HF3O2

Related Compounds