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hDDAH-1-IN-1 TFA

Names

[ CAS No. ]:
1229238-70-3

[ Name ]:
hDDAH-1-IN-1 TFA

Biological Activity

[Description]:

hDDAH-1-IN-1 TFA (compound 8a) is a potent and selective non-amino acid catalytic site inhibitor of human dimethylarginine dimethylaminohydrolase-1 (hDDAH-1), with a Ki of 18 µM[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Others >> Others
Research Areas >> Inflammation/Immunology

[In Vitro]

hDDAH-1-IN-1 TFA potently inhibits hDDAH-1 (Ki = 18 µM) without significantly affecting NOSs and arginase[1].

[References]

[1]. Lunk I, et al. Discovery of N-(4-Aminobutyl)-N'-(2-methoxyethyl)guanidine as the First Selective, Nonamino Acid, Catalytic Site Inhibitor of Human Dimethylarginine Dimethylaminohydrolase-1 (hDDAH-1). J Med Chem. 2019 Dec 31.

Chemical & Physical Properties

[ Molecular Formula ]:
C12H22F6N4O5

[ Molecular Weight ]:
416.32

Related Compounds