2768265-58-1
2768265-58-1 structure
- Name: Aha1/Hsp90-IN-1
- Chemical Name: Aha1/Hsp90-IN-1
- CAS Number: 2768265-58-1
- Molecular Formula: C22H17F3N4O2
- Molecular Weight: 426.39
- Catalog: Signaling Pathways Cell Cycle/DNA Damage Microtubule/Tubulin
- Create Date: 2022-10-12 13:38:53
- Modify Date: 2024-01-30 19:17:40
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Aha1/Hsp90-IN-1 (Compound 17) is an Aha1/Hsp90 complex inhibitor. Aha1/Hsp90-IN-1 disrupts Aha1/Hsp90 interactions with an IC50 of 3.32 μM. Aha1/Hsp90-IN-1 inhibits tau aggregation[1].
| Name | Aha1/Hsp90-IN-1 |
|---|
| Description | Aha1/Hsp90-IN-1 (Compound 17) is an Aha1/Hsp90 complex inhibitor. Aha1/Hsp90-IN-1 disrupts Aha1/Hsp90 interactions with an IC50 of 3.32 μM. Aha1/Hsp90-IN-1 inhibits tau aggregation[1]. |
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| Related Catalog | |
| Target |
IC50: 3.32 μM (Aha1/Hsp90 interactions)[1] |
| In Vitro | Aha1/Hsp90-IN-1 (Compound 17) (10 μM; 24 h) disrupts the Aha1/Hsp90 complex without direct inhibition of Hsp90 protein folding activity[1]. Western Blot Analysis[1] Cell Line: SH-SY5Y neuroblastoma cells and Her2 overexpressing SK-BR-3 breast cancer cells Concentration: 10 μM Incubation Time: 24 h Result: Exhibited the ability to disrupt interactions between Aha1 and Hsp90. Did not induce the degradation of Hsp90 client proteins Her2 (in SK-BR-3 cells), Cdk6, or pAktS473 (in SH SY5Y cells), nor do they induce the expression of Hsp70, a marker of the heat shock response. |
| References |
| Molecular Formula | C22H17F3N4O2 |
|---|---|
| Molecular Weight | 426.39 |