YAP-TEAD-IN-1

Names

[ CAS No. ]:
1659305-78-8

[ Name ]:
YAP-TEAD-IN-1

Biological Activity

[Description]:

YAP-TEAD-IN-1 is a potent and competitive inhibitor of YAP–TEAD interaction (IC50=25 nM). YAP-TEAD-IN-1 is a 17mer peptide and shows a higher the binding affinity to TEAD1 (Kd=15 nM) than YAP (50-171) (Kd=40 nM)[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Stem Cell/Wnt >> YAP

[Target]

IC50: 25 nM (YAP–TEAD interaction)[1]


[In Vitro]

YAP-TEAD-IN-1 (peptide 17)(2 μM) is against endogenous YAP binding to GST-TEAD (1209-426) in a GST pull-down assay, the Kd of His-YAP1209-426 is determined to be 40 nM[1].

[References]

[1]. Zhang Z, et al. Structure-Based Design and Synthesis of Potent Cyclic Peptides Inhibiting the YAP-TEAD Protein-Protein Interaction.ACS Med Chem Lett. 2014 Jul 14;5(9):993-8.

Chemical & Physical Properties

[ Molecular Formula ]:
C93H144ClN23O21S2

[ Molecular Weight ]:
2019.86

Related Compounds