CI-898 HCl
Modify Date: 2024-01-07 19:03:28
CI-898 HCl structure
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Common Name | CI-898 HCl | ||
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| CAS Number | 1658520-97-8 | Molecular Weight | 478.800 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C19H26Cl3N5O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of CI-898 HClTrimetrexate trihydrochloride is a antibiotic, also a potent dihydrofolate reductase (DHFR) inhibitor, reducing the production of DNA and RNA precursors and leading to cell death, with IC50 values of 4.74 nM and 1.35 nM for human DHFR and Toxoplasma gondii DHFR. Trimetrexate trihydrochloride can be used for researching Pneumocystis carinii pneumonia (PCP)[1][2]. |
| Name | 5-Methyl-6-{[(3,4,5-trimethoxyphenyl)amino]methyl}-2,4-quinazolinediamine trihydrochloride |
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| Synonym | More Synonyms |
| Description | Trimetrexate trihydrochloride is a antibiotic, also a potent dihydrofolate reductase (DHFR) inhibitor, reducing the production of DNA and RNA precursors and leading to cell death, with IC50 values of 4.74 nM and 1.35 nM for human DHFR and Toxoplasma gondii DHFR. Trimetrexate trihydrochloride can be used for researching Pneumocystis carinii pneumonia (PCP)[1][2]. |
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| Related Catalog | |
| Target |
IC50: 4.74 nM (human DHFR), 1.35 nM (Toxoplasma gondii DHFR)[1] |
| References |
[2]. Fulton, B., et al. Trimetrexate. Drugs 49, 563–576 (1995). |
| Molecular Formula | C19H26Cl3N5O3 |
|---|---|
| Molecular Weight | 478.800 |
| Exact Mass | 477.110138 |
| 2,4-Quinazolinediamine, 5-methyl-6-[[(3,4,5-trimethoxyphenyl)amino]methyl]-, hydrochloride (1:3) |
| 5-Methyl-6-{[(3,4,5-trimethoxyphenyl)amino]methyl}-2,4-quinazolinediamine trihydrochloride |