CI-898 HCl

Names

[ Name ]:
CI-898 HCl

[Synonym ]:
2,4-Quinazolinediamine, 5-methyl-6-[[(3,4,5-trimethoxyphenyl)amino]methyl]-, hydrochloride (1:3)
5-Methyl-6-{[(3,4,5-trimethoxyphenyl)amino]methyl}-2,4-quinazolinediamine trihydrochloride

Biological Activity

[Description]:

Trimetrexate trihydrochloride is a antibiotic, also a potent dihydrofolate reductase (DHFR) inhibitor, reducing the production of DNA and RNA precursors and leading to cell death, with IC50 values of 4.74 nM and 1.35 nM for human DHFR and Toxoplasma gondii DHFR. Trimetrexate trihydrochloride can be used for researching Pneumocystis carinii pneumonia (PCP)[1][2].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Cell Cycle/DNA Damage >> Antifolate

Signaling Pathways >> Anti-infection >> Bacterial

[Target]

IC50: 4.74 nM (human DHFR), 1.35 nM (Toxoplasma gondii DHFR)[1]

[References]

[1]. Hopper AT, et al. Discovery of Selective Toxoplasma gondii Dihydrofolate Reductase Inhibitors for the Treatment of Toxoplasmosis. J Med Chem. 2019 Feb 14;62(3):1562-1576.

[2]. Fulton, B., et al. Trimetrexate. Drugs 49, 563–576 (1995).

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₉H₂₆Cl₃N₅O₃

[ Molecular Weight ]:
478.800

[ Exact Mass ]:
477.110138

Related Compounds

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