1658520-97-8

1658520-97-8 structure

Name: CI-898 HCl
Chemical Name: 5-Methyl-6-{[(3,4,5-trimethoxyphenyl)amino]methyl}-2,4-quinazolinediamine trihydrochloride
CAS Number: 1658520-97-8
Molecular Formula: C₁₉H₂₆Cl₃N₅O₃
Molecular Weight: 478.800
Catalog: Signaling Pathways Anti-infection Bacterial
Create Date: 2021-01-12 11:18:12
Modify Date: 2024-01-07 19:03:28
Trimetrexate trihydrochloride is a antibiotic, also a potent dihydrofolate reductase (DHFR) inhibitor, reducing the production of DNA and RNA precursors and leading to cell death, with IC50 values of 4.74 nM and 1.35 nM for human DHFR and Toxoplasma gondii DHFR. Trimetrexate trihydrochloride can be used for researching Pneumocystis carinii pneumonia (PCP)[1][2].

Name	5-Methyl-6-{[(3,4,5-trimethoxyphenyl)amino]methyl}-2,4-quinazolinediamine trihydrochloride
Synonyms	2,4-Quinazolinediamine, 5-methyl-6-[[(3,4,5-trimethoxyphenyl)amino]methyl]-, hydrochloride (1:3) 5-Methyl-6-{[(3,4,5-trimethoxyphenyl)amino]methyl}-2,4-quinazolinediamine trihydrochloride

Description	Trimetrexate trihydrochloride is a antibiotic, also a potent dihydrofolate reductase (DHFR) inhibitor, reducing the production of DNA and RNA precursors and leading to cell death, with IC50 values of 4.74 nM and 1.35 nM for human DHFR and Toxoplasma gondii DHFR. Trimetrexate trihydrochloride can be used for researching Pneumocystis carinii pneumonia (PCP)[1][2].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Cell Cycle/DNA Damage >> Antifolate Signaling Pathways >> Anti-infection >> Bacterial
Target	IC50: 4.74 nM (human DHFR), 1.35 nM (Toxoplasma gondii DHFR)[1]
References	[1]. Hopper AT, et al. Discovery of Selective Toxoplasma gondii Dihydrofolate Reductase Inhibitors for the Treatment of Toxoplasmosis. J Med Chem. 2019 Feb 14;62(3):1562-1576. [2]. Fulton, B., et al. Trimetrexate. Drugs 49, 563–576 (1995).