82952-64-5
82952-64-5 structure
- Name: Trimetrexate glucuronate
- Chemical Name: CI 898 trihydrochloride,5-Methyl-6-[[(3,4,5-trimethoxyphenyl)amino]methyl]-2,4-quinazolinediaminetrihydrochloride
- CAS Number: 82952-64-5
- Molecular Formula: C25H33N5O10
- Molecular Weight: 563.55700
- Catalog: Signaling Pathways Anti-infection Bacterial
- Create Date: 2018-02-28 08:00:00
- Modify Date: 2023-01-17 20:37:05
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Trimetrexate glucuronate (NSC 352122) is a folic acid antagonist. Trimetrexate glucuronate affects DNA and RNA synthesis by inhibiting dihydrofolate reductase and preventing the synthesis of purine nucleotides and thymidylate. Trimetrexate glucuronate has potential anti-tumour activity[1].
| Name | CI 898 trihydrochloride,5-Methyl-6-[[(3,4,5-trimethoxyphenyl)amino]methyl]-2,4-quinazolinediaminetrihydrochloride |
|---|---|
| Synonyms |
CI 898 dihydrochloride
CI 898 TRIHYDROCHLORIDE Trimetrexate glucuronate |
| Description | Trimetrexate glucuronate (NSC 352122) is a folic acid antagonist. Trimetrexate glucuronate affects DNA and RNA synthesis by inhibiting dihydrofolate reductase and preventing the synthesis of purine nucleotides and thymidylate. Trimetrexate glucuronate has potential anti-tumour activity[1]. |
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| Related Catalog | |
| In Vitro | Trimetrexate glucuronate (0.05-1 μM 6 h) results in a decrease in adenosine and guanosine acids and a significant increase in the pyrimidine nucleotide such as CTP, UTP of WI-L2 human lymphoblastoid cells in a dose-dependent manner[1]. Trimetrexate glucuronate (1 μM, 2 h) can reduce the level of dTTP by 29%, also decrease in the dGTP and dATP, while cause extensive inhibition of deoxyuridine incorporation into DNA in L1210 mouse leukemia cells[1]. |
| In Vivo | Trimetrexate glucuronate (i.p., 100-225 mg/kg, daily, day 1, 5, 9) has antitumor activity in inbred DBA/2 mice with L1210 leukemia[1]. Animal Model: Inbred DBA/2 mice with L1210 leukemia[1] Dosage: 100, 150, 225 mg/kg Administration: Intraperitoneal injection; daily; day 1, 5, 9 Result: Showed the maximum lifespan T/C value of 171%. Animal Model: C57BL/6 mice with M5076 tumor[1] Dosage: 38, 62 mg/kg Administration: Intraperitoneal injection; daily; 1-9 days Result: Showed toxic (>10% early deaths) at high dose of 62 mg/kg and inactive (Lifespan T/C <130%) at lower dose of 38 mg/kg. |
| References |
| Density | 1.305 g/cm3 |
|---|---|
| Boiling Point | 647ºC at 760 mmHg |
| Molecular Formula | C25H33N5O10 |
| Molecular Weight | 563.55700 |
| Flash Point | 345.1ºC |
| Exact Mass | 563.22300 |
| PSA | 244.99000 |
| LogP | 0.84680 |
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