Dapsone-13C12

Modify Date: 2024-04-09 16:32:41

Dapsone-13C12 Structure
Dapsone-13C12 structure
Common Name Dapsone-13C12
CAS Number 1632119-29-9 Molecular Weight 260.21
Density N/A Boiling Point N/A
Molecular Formula 13C12H12N2O2S Melting Point N/A
MSDS Chinese USA Flash Point N/A
Symbol GHS07
GHS07
Signal Word Warning

 Use of Dapsone-13C12


Dapsone-13C12 is the 13C12 labeled Dapsone. Dapsone (4,4′-Diaminodiphenyl sulfone) is an orally active and blood-brain penetrant sulfonamide antibiotic with bacteriostatic, antimycobacterial and antiprotozoal activities[1]. Dapsone exerts effective antileprosy activity and inhibits folate synthesis in cell extracts of M. leprae. Dapsone is used for dermatologic disorder research, including leprosy, dermatitis herpetiformis, acne vulgaris et al.

 Names

Name Dapsone-13C12

 Dapsone-13C12 Biological Activity

Description Dapsone-13C12 is the 13C12 labeled Dapsone. Dapsone (4,4′-Diaminodiphenyl sulfone) is an orally active and blood-brain penetrant sulfonamide antibiotic with bacteriostatic, antimycobacterial and antiprotozoal activities[1]. Dapsone exerts effective antileprosy activity and inhibits folate synthesis in cell extracts of M. leprae. Dapsone is used for dermatologic disorder research, including leprosy, dermatitis herpetiformis, acne vulgaris et al.
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-223.

[2]. Y I Zhu, et al. Dapsone and sulfones in dermatology: overview and update. J Am Acad Dermatol

[3]. Dapsone, Drug.com

[4]. D Voeller, et al. Interaction of Pneumocystis carinii dihydropteroate synthase with sulfonamides and diaminodiphenyl sulfone (dapsone).J Infect Dis. 1994 Feb;169(2):456-9.

[5]. Esther Moreno, et al. Evaluation of Skin Permeation and Retention of Topical Dapsone in Murine Cutaneous Leishmaniasis Lesions.Pharmaceutics. 2019 Nov 13;11(11):607.

 Chemical & Physical Properties

Molecular Formula 13C12H12N2O2S
Molecular Weight 260.21

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302
RIDADR NONH for all modes of transport
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