Phenylbutazone-13C12

Modify Date: 2024-01-17 08:50:44

Phenylbutazone-13C12 Structure
Phenylbutazone-13C12 structure
Common Name Phenylbutazone-13C12
CAS Number 1325559-13-4 Molecular Weight 320.286
Density 1.2±0.1 g/cm3 Boiling Point N/A
Molecular Formula C713C12H20N2O2 Melting Point N/A
MSDS USA Flash Point N/A
Symbol GHS07
GHS07
Signal Word Warning

 Use of Phenylbutazone-13C12


Phenylbutazone-13C12 is the 13C12 labeled Phenylbutazone. Phenylbutazone is an efficient reducing cofactor for the peroxidase activity of prostaglandin H synthase (PHS). Phenylbutazone, a hepatotoxin, is a nonsteroidal anti-inflammatory drug (NSAID). Phenylbutazone induces muscle blind-like protein 1 (MBNL1) expression and has the potential for ankylosing spondylitis research.

 Names

Name Phenylbutazone-13C12
Synonym More Synonyms

 Phenylbutazone-13C12 Biological Activity

Description Phenylbutazone-13C12 is the 13C12 labeled Phenylbutazone. Phenylbutazone is an efficient reducing cofactor for the peroxidase activity of prostaglandin H synthase (PHS). Phenylbutazone, a hepatotoxin, is a nonsteroidal anti-inflammatory drug (NSAID). Phenylbutazone induces muscle blind-like protein 1 (MBNL1) expression and has the potential for ankylosing spondylitis research.
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-223.

[2]. G A Reed, et al. Inactivation of prostaglandin H synthase and prostacyclin synthase by phenylbutazone. Requirement for peroxidative metabolism. Mol Pharmacol. 1985 Jan;27(1):109-14.

[3]. Guiying Chen, et al. Phenylbutazone induces expression of MBNL1 and suppresses formation of MBNL1-CUG RNA foci in a mouse model of myotonic dystrophy. Sci Rep. 2016 Apr 29;6:25317.

[4]. Beretta C, et al. COX-1 and COX-2 inhibition in horse blood by phenylbutazone, flunixin, carprofen and meloxicam: an in vitro analysis. Pharmacol Res. 2005 Oct;52(4):302-6.

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Molecular Formula C713C12H20N2O2
Molecular Weight 320.286
Exact Mass 320.192749
Index of Refraction 1.590

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302-H312-H315-H319-H332-H335
Precautionary Statements P261-P280-P305 + P351 + P338
Hazard Codes Xn
Risk Phrases 20/21/22-36/37/38
Safety Phrases 26-36/37
RIDADR NONH for all modes of transport

 Synonyms

4-Butyl-1,2-bis[(13C6)phenyl]-3,5-pyrazolidinedione
3,5-Pyrazolidinedione, 4-butyl-1,2-di(phenyl-13C6)-
4-Butyl-1,2-diphenyl-13C12-pyrazolidine-3,5-dione
MFCD19704819
Phenylbutazone-(diphenyl-13C12)