1325559-13-4

1325559-13-4 structure

Name: Phenylbutazone-13C12
Chemical Name: Phenylbutazone-13C12
CAS Number: 1325559-13-4
Molecular Formula: C₇₁₃C₁₂H₂₀N₂O₂
Molecular Weight: 320.286
Catalog: analytical chemistry Standard Forensic and veterinary standards
Create Date: 2019-01-20 21:07:33
Modify Date: 2024-01-17 08:50:44
Phenylbutazone-13C12 is the 13C12 labeled Phenylbutazone. Phenylbutazone is an efficient reducing cofactor for the peroxidase activity of prostaglandin H synthase (PHS). Phenylbutazone, a hepatotoxin, is a nonsteroidal anti-inflammatory drug (NSAID). Phenylbutazone induces muscle blind-like protein 1 (MBNL1) expression and has the potential for ankylosing spondylitis research.

Name	Phenylbutazone-13C12
Synonyms	4-Butyl-1,2-bis[(13C6)phenyl]-3,5-pyrazolidinedione 3,5-Pyrazolidinedione, 4-butyl-1,2-di(phenyl-13C6)- 4-Butyl-1,2-diphenyl-13C12-pyrazolidine-3,5-dione MFCD19704819 Phenylbutazone-(diphenyl-13C12)

Description	Phenylbutazone-13C12 is the 13C12 labeled Phenylbutazone. Phenylbutazone is an efficient reducing cofactor for the peroxidase activity of prostaglandin H synthase (PHS). Phenylbutazone, a hepatotoxin, is a nonsteroidal anti-inflammatory drug (NSAID). Phenylbutazone induces muscle blind-like protein 1 (MBNL1) expression and has the potential for ankylosing spondylitis research.
Related Catalog	Research Areas >> Inflammation/Immunology Signaling Pathways >> Immunology/Inflammation >> COX
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-223. [2]. G A Reed, et al. Inactivation of prostaglandin H synthase and prostacyclin synthase by phenylbutazone. Requirement for peroxidative metabolism. Mol Pharmacol. 1985 Jan;27(1):109-14. [3]. Guiying Chen, et al. Phenylbutazone induces expression of MBNL1 and suppresses formation of MBNL1-CUG RNA foci in a mouse model of myotonic dystrophy. Sci Rep. 2016 Apr 29;6:25317. [4]. Beretta C, et al. COX-1 and COX-2 inhibition in horse blood by phenylbutazone, flunixin, carprofen and meloxicam: an in vitro analysis. Pharmacol Res. 2005 Oct;52(4):302-6.

Density	1.2±0.1 g/cm3
Molecular Formula	C₇₁₃C₁₂H₂₀N₂O₂
Molecular Weight	320.286
Exact Mass	320.192749
Index of Refraction	1.590

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302-H312-H315-H319-H332-H335
Precautionary Statements	P261-P280-P305 + P351 + P338
Hazard Codes	Xn
Risk Phrases	20/21/22-36/37/38
Safety Phrases	26-36/37
RIDADR	NONH for all modes of transport

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