NITD-564
Modify Date: 2025-11-25 12:09:37
NITD-564 structure
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Common Name | NITD-564 | ||
|---|---|---|---|---|
| CAS Number | 1614262-75-7 | Molecular Weight | 283.371 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C18H21NO2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of NITD-564NITD-564 is a novel, direct inhibitor of the mycobacterial enoyl-reductase InhA with IC50 of 0.59 uM, exhibits MIC50 of 160 nM against Mtb; binds specifically to InhA in an NADH-dependent manner and blocks the enoyl substrate-binding pocket; shows in vivo efficacy in acute and established mouse models of Mycobacterium tuberculosis infection. |
| Name | NITD-564 |
|---|
| Description | NITD-564 is a novel, direct inhibitor of the mycobacterial enoyl-reductase InhA with IC50 of 0.59 uM, exhibits MIC50 of 160 nM against Mtb; binds specifically to InhA in an NADH-dependent manner and blocks the enoyl substrate-binding pocket; shows in vivo efficacy in acute and established mouse models of Mycobacterium tuberculosis infection. |
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| References | References 1. Manjunatha UH, et al. Sci Transl Med. 2015 Jan 7;7(269):269ra3. View Related Products by Target Bacterial |
| Molecular Formula | C18H21NO2 |
|---|---|
| Molecular Weight | 283.371 |
| InChIKey | UVVRYOIOMHFQGU-UHFFFAOYSA-N |
| SMILES | O=c1[nH]c(CC2CCCCC2)cc(O)c1-c1ccccc1 |