NITD-564

Names

[ Name ]:
NITD-564

Biological Activity

[Description]:

NITD-564 is a novel, direct inhibitor of the mycobacterial enoyl-reductase InhA with IC50 of 0.59 uM, exhibits MIC50 of 160 nM against Mtb; binds specifically to InhA in an NADH-dependent manner and blocks the enoyl substrate-binding pocket; shows in vivo efficacy in acute and established mouse models of Mycobacterium tuberculosis infection.

[References]

References 1. Manjunatha UH, et al. Sci Transl Med. 2015 Jan 7;7(269):269ra3. View Related Products by Target Bacterial

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₈H₂₁NO₂

[ Molecular Weight ]:
283.371

Related Compounds

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