1614262-75-7
1614262-75-7 structure
- Name: NITD-564
- Chemical Name: NITD-564
- CAS Number: 1614262-75-7
- Molecular Formula: C18H21NO2
- Molecular Weight: 283.371
- Create Date: 2020-01-12 09:27:51
- Modify Date: 2024-04-06 18:04:48
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NITD-564 is a novel, direct inhibitor of the mycobacterial enoyl-reductase InhA with IC50 of 0.59 uM, exhibits MIC50 of 160 nM against Mtb; binds specifically to InhA in an NADH-dependent manner and blocks the enoyl substrate-binding pocket; shows in vivo efficacy in acute and established mouse models of Mycobacterium tuberculosis infection.
| Name | NITD-564 |
|---|
| Description | NITD-564 is a novel, direct inhibitor of the mycobacterial enoyl-reductase InhA with IC50 of 0.59 uM, exhibits MIC50 of 160 nM against Mtb; binds specifically to InhA in an NADH-dependent manner and blocks the enoyl substrate-binding pocket; shows in vivo efficacy in acute and established mouse models of Mycobacterium tuberculosis infection. |
|---|---|
| References | References 1. Manjunatha UH, et al. Sci Transl Med. 2015 Jan 7;7(269):269ra3. View Related Products by Target Bacterial |
| Molecular Formula | C18H21NO2 |
|---|---|
| Molecular Weight | 283.371 |