1473450-60-0

1473450-60-0 structure

Name: NITD-304
Chemical Name: 4,6-Dichloro-N-(4,4-dimethylcyclohexyl)-1H-indole-2-carboxamide
CAS Number: 1473450-60-0
Molecular Formula: C₁₇H₂₀Cl₂N₂O
Molecular Weight: 339.259
Create Date: 2020-01-12 03:27:50
Modify Date: 2024-04-03 15:32:28
NITD-304 is a novel, orally bioavailable mycobacterial membrane protein Large 3 (MmpL3) inhibitor with MIC of 15 nM against M tuberculosis H37Rv; shows potent activity against both drug-sensitive and multidrug-resistant clinical isolates of Mtb; demonstrates effectivity in treating both acute and chronic Mtb infections in mouse efficacy models.

Name	4,6-Dichloro-N-(4,4-dimethylcyclohexyl)-1H-indole-2-carboxamide
Synonyms	4,6-Dichloro-N-(4,4-dimethylcyclohexyl)-1H-indole-2-carboxamide MFCD28502067 1H-Indole-2-carboxamide, 4,6-dichloro-N-(4,4-dimethylcyclohexyl)-

Description	NITD-304 is a novel, orally bioavailable mycobacterial membrane protein Large 3 (MmpL3) inhibitor with MIC of 15 nM against M tuberculosis H37Rv; shows potent activity against both drug-sensitive and multidrug-resistant clinical isolates of Mtb; demonstrates effectivity in treating both acute and chronic Mtb infections in mouse efficacy models.
References	References 1. Rao SP, et al. Sci Transl Med. 2013 Dec 4;5(214):214ra168. View Related Products by Target Bacterial