NITD-304
Modify Date: 2025-11-12 12:38:07
NITD-304 structure
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Common Name | NITD-304 | ||
|---|---|---|---|---|
| CAS Number | 1473450-60-0 | Molecular Weight | 339.259 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 551.5±45.0 °C at 760 mmHg | |
| Molecular Formula | C17H20Cl2N2O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 287.3±28.7 °C | |
Use of NITD-304NITD-304 is a novel, orally bioavailable mycobacterial membrane protein Large 3 (MmpL3) inhibitor with MIC of 15 nM against M tuberculosis H37Rv; shows potent activity against both drug-sensitive and multidrug-resistant clinical isolates of Mtb; demonstrates effectivity in treating both acute and chronic Mtb infections in mouse efficacy models. |
| Name | 4,6-Dichloro-N-(4,4-dimethylcyclohexyl)-1H-indole-2-carboxamide |
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| Synonym | More Synonyms |
| Description | NITD-304 is a novel, orally bioavailable mycobacterial membrane protein Large 3 (MmpL3) inhibitor with MIC of 15 nM against M tuberculosis H37Rv; shows potent activity against both drug-sensitive and multidrug-resistant clinical isolates of Mtb; demonstrates effectivity in treating both acute and chronic Mtb infections in mouse efficacy models. |
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| References | References 1. Rao SP, et al. Sci Transl Med. 2013 Dec 4;5(214):214ra168. View Related Products by Target Bacterial |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 551.5±45.0 °C at 760 mmHg |
| Molecular Formula | C17H20Cl2N2O |
| Molecular Weight | 339.259 |
| Flash Point | 287.3±28.7 °C |
| Exact Mass | 338.095276 |
| LogP | 6.10 |
| Vapour Pressure | 0.0±1.5 mmHg at 25°C |
| Index of Refraction | 1.620 |
| InChIKey | NKNGAORFGPSYJG-UHFFFAOYSA-N |
| SMILES | CC1(C)CCC(NC(=O)c2cc3c(Cl)cc(Cl)cc3[nH]2)CC1 |
| 4,6-Dichloro-N-(4,4-dimethylcyclohexyl)-1H-indole-2-carboxamide |
| MFCD28502067 |
| 1H-Indole-2-carboxamide, 4,6-dichloro-N-(4,4-dimethylcyclohexyl)- |