NITD-609
Modify Date: 2024-01-02 10:13:00
NITD-609 structure
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Common Name | NITD-609 | ||
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| CAS Number | 1193314-23-6 | Molecular Weight | 390.238 | |
| Density | 1.6±0.1 g/cm3 | Boiling Point | 621.3±55.0 °C at 760 mmHg | |
| Molecular Formula | C19H14Cl2FN3O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 329.6±31.5 °C | |
Use of NITD-609Cipargamin (NITD609) is an potent antimalarial compound, with IC50 of appr 1 nM against P. falciparum. |
| Name | (3R,3'S)-5,7'-dichloro-6'-fluoro-3'-methylspiro[1H-indole-3,1'-2,3,4,9-tetrahydropyrido[3,4-b]indole]-2-one |
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| Synonym | More Synonyms |
| Description | Cipargamin (NITD609) is an potent antimalarial compound, with IC50 of appr 1 nM against P. falciparum. |
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| Related Catalog | |
| Target |
IC50: 1 nM (P. falciparum)[3] |
| In Vitro | Cipargamin (NITD609) inhibits T. gondii with a MIC90 for tachyzoites of 5 μM and a MIC50 of 1 μM, without toxicity to human foreskin fibroblasts (HFFs) at the highest concentration tested (10 μM)[1]. Cipargamin (NITD609) is the most effective inhibitor of early gametocyte development at 50 and 500 nM. Cipargamin shows a dose-dependent inhibiting effect on late gametocyte development[2]. Cipargamin (NITD609) shows potent activities against a panel of culture-adapted P. falciparum strains, with ICIC50 values of 0.5-1.4 nM. Cipargamin is effective as artesunate with potency in the low nanomolar range (ICIC50 values consistently <10 nM) against all P. falciparum and P. vivax isolates[3]. |
| In Vivo | Cipargamin (NITD609) shows favorable pharmacokinetic properties and displays single dose cure efficacy in a malaria mouse model. Cipargamin (100 mg/kg) completely clears P. berghei infection in all treated mice, and partial cure (50%) is achieved with a single oral dose at 30 mg/kg[3]. |
| References |
| Density | 1.6±0.1 g/cm3 |
|---|---|
| Boiling Point | 621.3±55.0 °C at 760 mmHg |
| Molecular Formula | C19H14Cl2FN3O |
| Molecular Weight | 390.238 |
| Flash Point | 329.6±31.5 °C |
| Exact Mass | 389.049805 |
| PSA | 60.41000 |
| LogP | 4.61 |
| Vapour Pressure | 0.0±1.8 mmHg at 25°C |
| Index of Refraction | 1.738 |
| (1R,3S)-5',7-Dichloro-6-fluoro-3-methyl-2,3,4,9-tetrahydrospiro[β-carboline-1,3'-indol]-2'(1'H)-one |
| NITD609 |
| cipargamin |
| nitd 609 |
| Spiro[3H-indole-3,1'-[1H]pyrido[3,4-b]indol]-2(1H)-one, 5,7'-dichloro-6'-fluoro-2',3',4',9'-tetrahydro-3'-methyl-, (3R,3'S)- |
| KAE609 |