NITD-916
Modify Date: 2024-01-12 07:14:21
NITD-916 structure
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Common Name | NITD-916 | ||
|---|---|---|---|---|
| CAS Number | 1614262-83-7 | Molecular Weight | 311.425 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C20H25NO2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of NITD-916NITD-916 is a novel, direct inhibitor of the mycobacterial enoyl-reductase InhA with IC50 of 0.57 uM, exhibits MIC50 of 50 nM against Mtb; shows MIC of 0.04 to 0.16 μM against MDR-Mtb strains, binds specifically to InhA in an NADH-dependent manner and blocks the enoyl substrate-binding pocket; shows in vivo efficacy in acute and established mouse models of Mycobacterium tuberculosis infection. |
| Name | NITD-916 |
|---|
| Description | NITD-916 is a novel, direct inhibitor of the mycobacterial enoyl-reductase InhA with IC50 of 0.57 uM, exhibits MIC50 of 50 nM against Mtb; shows MIC of 0.04 to 0.16 μM against MDR-Mtb strains, binds specifically to InhA in an NADH-dependent manner and blocks the enoyl substrate-binding pocket; shows in vivo efficacy in acute and established mouse models of Mycobacterium tuberculosis infection. |
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| References | References 1. Manjunatha UH, et al. Sci Transl Med. 2015 Jan 7;7(269):269ra3. 2. McNeil MB, et al. Tuberculosis (Edinb). 2017 Dec;107:133-136. View Related Products by Target Bacterial |
| Molecular Formula | C20H25NO2 |
|---|---|
| Molecular Weight | 311.425 |