NITD-304

Names

[ Name ]:
NITD-304

[Synonym ]:
4,6-Dichloro-N-(4,4-dimethylcyclohexyl)-1H-indole-2-carboxamide
MFCD28502067
1H-Indole-2-carboxamide, 4,6-dichloro-N-(4,4-dimethylcyclohexyl)-

Biological Activity

[Description]:

NITD-304 is a novel, orally bioavailable mycobacterial membrane protein Large 3 (MmpL3) inhibitor with MIC of 15 nM against M tuberculosis H37Rv; shows potent activity against both drug-sensitive and multidrug-resistant clinical isolates of Mtb; demonstrates effectivity in treating both acute and chronic Mtb infections in mouse efficacy models.

[References]

References 1. Rao SP, et al. Sci Transl Med. 2013 Dec 4;5(214):214ra168. View Related Products by Target Bacterial

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
551.5±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₇H₂₀Cl₂N₂O

[ Molecular Weight ]:
339.259

[ Flash Point ]:
287.3±28.7 °C

[ Exact Mass ]:
338.095276

[ LogP ]:
6.10

[ Vapour Pressure ]:
0.0±1.5 mmHg at 25°C

[ Index of Refraction ]:
1.620

Related Compounds

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