Bis-propargyl-PEG4

Modify Date: 2024-01-08 19:37:45

Bis-propargyl-PEG4 Structure
Bis-propargyl-PEG4 structure
Common Name Bis-propargyl-PEG4
CAS Number 159428-42-9 Molecular Weight 270.322
Density 1.0±0.1 g/cm3 Boiling Point 338.7±37.0 °C at 760 mmHg
Molecular Formula C14H22O5 Melting Point N/A
MSDS N/A Flash Point 130.7±26.4 °C

 Use of Bis-propargyl-PEG4


Bis-propargyl-PEG4 is a PEG-based PROTAC linker used in the synthesis of PROTACs. Bis-propargyl-PEG4 is used for the synthesis of demethylvancomycin dimers[1][2].

 Names

Name 4,7,10,13,16-Pentaoxanonadeca-1,18-diyne
Synonym More Synonyms

 Bis-propargyl-PEG4 Biological Activity

Description Bis-propargyl-PEG4 is a PEG-based PROTAC linker used in the synthesis of PROTACs. Bis-propargyl-PEG4 is used for the synthesis of demethylvancomycin dimers[1][2].
Related Catalog
In Vitro Bis-propargyl-PEG4 can be used in the synthesis of demethylvancomycin dimers against vancomycin-resistant enterococcus faecalis[2].
References

[1]. Pearlie BURNETTE, et al. Dimeric immuno-modulatory compounds against cereblon-based mechanisms. WO2020014489A2.

[2]. Jiang, et al. Design, synthesis and biological activity of novel demethylvancomycin dimers against vancomycin-resistant enterococcus faecalis. Tetrahedron, 2018: 74(27), 3527–3533.

 Chemical & Physical Properties

Density 1.0±0.1 g/cm3
Boiling Point 338.7±37.0 °C at 760 mmHg
Molecular Formula C14H22O5
Molecular Weight 270.322
Flash Point 130.7±26.4 °C
Exact Mass 270.146729
LogP -0.41
Vapour Pressure 0.0±0.7 mmHg at 25°C
Index of Refraction 1.463

 Safety Information

Hazard Codes Xi

 Synonyms

MFCD22201533
4,7,10,13,16-Pentaoxanonadeca-1,18-diyne