α-Helical CRF (12-41) trifluoroacetate salt

Modify Date: 2025-08-24 10:44:41

α-Helical CRF (12-41) trifluoroacetate salt structure	Common Name	α-Helical CRF (12-41) trifluoroacetate salt
	CAS Number	158535-55-8	Molecular Weight	3497.009
	Density	1.5±0.1 g/cm3	Boiling Point	N/A
	Molecular Formula	C₁₅₂H₂₅₁N₄₃O₄₇S₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of α-Helical CRF (12-41) trifluoroacetate salt

a-Helical Corticotropin Releasing Factor (12-41) is a 30 amino acids long, α-helical analogue of corticotropin releasing factor/hormone. Corticotropin releasing factor (CRF) is a hypothalamic hormone, which stimulates the secretion of adrenocorticotrophic hormone (ACTH). a-Helical Corticotropin Releasing Factor (12-41) would suppress the stimulatory effect[1][2].

Name	L-Phenylalanyl-L-histidyl-L-leucyl-L-leucyl-L-arginyl-L-α-glutamyl-L-methionyl-L-leucyl-L-α-glutamyl-L-methionyl-L-alanyl-L-lysyl-L-alanyl-L-α-glutamyl-L-glutaminyl-L-α-glutamyl-L-alanyl-L-α-glutamyl-L-glutaminyl-L-alanyl-L-alanyl-L-leucyl-L-asparaginyl-L-arginyl-L-leucyl-L-leucyl-L-leucyl-L-α-glutamyl-L-α-glutamyl-L-alaninamide
Synonym	More Synonyms

Description	a-Helical Corticotropin Releasing Factor (12-41) is a 30 amino acids long, α-helical analogue of corticotropin releasing factor/hormone. Corticotropin releasing factor (CRF) is a hypothalamic hormone, which stimulates the secretion of adrenocorticotrophic hormone (ACTH). a-Helical Corticotropin Releasing Factor (12-41) would suppress the stimulatory effect[1][2].
Related Catalog	Research Areas >> Endocrinology Signaling Pathways >> GPCR/G Protein >> CRFR
In Vitro	a-Helical Corticotropin Releasing Factor (0.3 nM; 5-min pulses every 40 min alternately) shows the inhibitory effect on stimulated release of immunoreactive ACTH from perifused equine anterior pituitary cells in vitro.[2]. a-Helical Corticotropin Releasing Factor (0.5-5 μM) suppresses CRH-induced ACTH secretion[2].
In Vivo	a-Helical Corticotropin Releasing Factor (12-41) (15-150 μg; s.c.; isolated for 30 or 60 min) suppresses the active behavioral response characteristic of guinea pig pups to brief isolation in novel surroundings[1]. Animal Model: Guinea pig pups (20-26 days old and )[1] Dosage: 15, 50, 150 μg per animal Administration: Subcutaneous injection; isolated in novel surroundings for 30 min or 60 min. Result: Resulted pups vocalized more and exhibited more locomotor activity in 20- to 26-day-old pups. Increased levels of vocalizing in isolated 4- to 6-day-old pups at 50 μg dose, though no changes were seen in locomotor activity.
References	[1]. Hennessy MB, et al. Evidence that endogenous corticotropin-releasing factor suppresses behavioral responses of guinea pig pups to brief isolation in novel surroundings. Dev Psychobiol. 1997 Jul;31(1):39-47. [2]. Ellis M J, et al. The effects of corticotrophin-releasing hormone, arginine vasopressin and their antagonists on ACTH release from perifused horse anterior pituitary cells[J]. Journal of endocrinology, 1994, 143(1): 85-93.

Density	1.5±0.1 g/cm3
Molecular Formula	C₁₅₂H₂₅₁N₄₃O₄₇S₂
Molecular Weight	3497.009
Exact Mass	3494.801514
LogP	-5.94
Index of Refraction	1.644

L-Alaninamide, L-phenylalanyl-L-histidyl-L-leucyl-L-leucyl-L-arginyl-L-α-glutamyl-L-methionyl-L-leucyl-L-α-glutamyl-L-methionyl-L-alanyl-L-lysyl-L-alanyl-L-α-glutamyl-L-glutaminyl-L-α- 
glutamyl-L-alanyl-L-α-glutamyl-L-glutaminyl-L-alanyl-L-alanyl-L-leucyl-L-asparaginyl-L-arginyl-L-leucyl-L-leucyl-L-leucyl-L-α-glutamyl-L-α-glutamyl-

L-Phenylalanyl-L-histidyl-L-leucyl-L-leucyl-L-arginyl-L-α-glutamyl-L-methionyl-L-leucyl-L-α-glutamyl-L-methionyl-L-alanyl-L-lysyl-L-alanyl-L-α-glutamyl-L-glutaminyl-L-α-glutamyl-L-alan 
yl-L-α-glutamyl-L-glutaminyl-L-alanyl-L-alanyl-L-leucyl-L-asparaginyl-L-arginyl-L-leucyl-L-leucyl-L-leucyl-L-α-glutamyl-L-α-glutamyl-L-alaninamide

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Nanjing Peptide Biotech Ltd
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Product Name: α-Helical CRF (12-41)
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: a-Helical Corticotropin Releasing Factor (12-41)
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Purity: 98.0%
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