- Nanjing Peptide Biotech Ltd
- China
- Product Name: α-Helical CRF (12-41)
- Price: ￥Inquiry/10g ￥Inquiry/100g ￥Inquiry/1kg ￥Inquiry/10kg
- Purity: 98.0%
- Stocking Period: 7 Day
- Contact: jom
- Dayang Chem (Hangzhou) Co., Ltd.
- China
- Product Name: a-Helical Corticotropin Releasing Factor (12-41)
- Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
- Purity: 98.0%
- Stocking Period: Inquiry
- Contact: Ms Wang
- Zhejiang Hangyu API Co., Ltd
- China
- Product Name: α-Helical CRF (12-41)
- Price: $Inquiry/1kg
- Purity: 99.0%
- Stocking Period: 1 Day
- Contact: Vinnie
158535-55-8
158535-55-8 structure
- Name: α-Helical CRF (12-41) trifluoroacetate salt
- Chemical Name: L-Phenylalanyl-L-histidyl-L-leucyl-L-leucyl-L-arginyl-L-α-glutamyl-L-methionyl-L-leucyl-L-α-glutamyl-L-methionyl-L-alanyl-L-lysyl-L-alanyl-L-α-glutamyl-L-glutaminyl-L-α-glutamyl-L-alanyl-L-α-glutamyl-L-glutaminyl-L-alanyl-L-alanyl-L-leucyl-L-asparaginyl-L-arginyl-L-leucyl-L-leucyl-L-leucyl-L-α-glutamyl-L-α-glutamyl-L-alaninamide
- CAS Number: 158535-55-8
- Molecular Formula: C152H251N43O47S2
- Molecular Weight: 3497.009
- Catalog: Signaling Pathways GPCR/G Protein CRFR
- Create Date: 2018-06-30 15:49:39
- Modify Date: 2024-01-10 17:03:13
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a-Helical Corticotropin Releasing Factor (12-41) is a 30 amino acids long, α-helical analogue of corticotropin releasing factor/hormone. Corticotropin releasing factor (CRF) is a hypothalamic hormone, which stimulates the secretion of adrenocorticotrophic hormone (ACTH). a-Helical Corticotropin Releasing Factor (12-41) would suppress the stimulatory effect[1][2].
| Name | L-Phenylalanyl-L-histidyl-L-leucyl-L-leucyl-L-arginyl-L-α-glutamyl-L-methionyl-L-leucyl-L-α-glutamyl-L-methionyl-L-alanyl-L-lysyl-L-alanyl-L-α-glutamyl-L-glutaminyl-L-α-glutamyl-L-alanyl-L-α-glutamyl-L-glutaminyl-L-alanyl-L-alanyl-L-leucyl-L-asparaginyl-L-arginyl-L-leucyl-L-leucyl-L-leucyl-L-α-glutamyl-L-α-glutamyl-L-alaninamide |
|---|---|
| Synonyms |
L-Alaninamide, L-phenylalanyl-L-histidyl-L-leucyl-L-leucyl-L-arginyl-L-α-glutamyl-L-methionyl-L-leucyl-L-α-glutamyl-L-methionyl-L-alanyl-L-lysyl-L-alanyl-L-α-glutamyl-L-glutaminyl-L-α- 
glutamyl-L-alanyl-L-α-glutamyl-L-glutaminyl-L-alanyl-L-alanyl-L-leucyl-L-asparaginyl-L-arginyl-L-leucyl-L-leucyl-L-leucyl-L-α-glutamyl-L-α-glutamyl-
L-Phenylalanyl-L-histidyl-L-leucyl-L-leucyl-L-arginyl-L-α-glutamyl-L-methionyl-L-leucyl-L-α-glutamyl-L-methionyl-L-alanyl-L-lysyl-L-alanyl-L-α-glutamyl-L-glutaminyl-L-α-glutamyl-L-alan 
yl-L-α-glutamyl-L-glutaminyl-L-alanyl-L-alanyl-L-leucyl-L-asparaginyl-L-arginyl-L-leucyl-L-leucyl-L-leucyl-L-α-glutamyl-L-α-glutamyl-L-alaninamide |
| Description | a-Helical Corticotropin Releasing Factor (12-41) is a 30 amino acids long, α-helical analogue of corticotropin releasing factor/hormone. Corticotropin releasing factor (CRF) is a hypothalamic hormone, which stimulates the secretion of adrenocorticotrophic hormone (ACTH). a-Helical Corticotropin Releasing Factor (12-41) would suppress the stimulatory effect[1][2]. |
|---|---|
| Related Catalog | |
| In Vitro | a-Helical Corticotropin Releasing Factor (0.3 nM; 5-min pulses every 40 min alternately) shows the inhibitory effect on stimulated release of immunoreactive ACTH from perifused equine anterior pituitary cells in vitro.[2]. a-Helical Corticotropin Releasing Factor (0.5-5 μM) suppresses CRH-induced ACTH secretion[2]. |
| In Vivo | a-Helical Corticotropin Releasing Factor (12-41) (15-150 μg; s.c.; isolated for 30 or 60 min) suppresses the active behavioral response characteristic of guinea pig pups to brief isolation in novel surroundings[1]. Animal Model: Guinea pig pups (20-26 days old and )[1] Dosage: 15, 50, 150 μg per animal Administration: Subcutaneous injection; isolated in novel surroundings for 30 min or 60 min. Result: Resulted pups vocalized more and exhibited more locomotor activity in 20- to 26-day-old pups. Increased levels of vocalizing in isolated 4- to 6-day-old pups at 50 μg dose, though no changes were seen in locomotor activity. |
| References |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Molecular Formula | C152H251N43O47S2 |
| Molecular Weight | 3497.009 |
| Exact Mass | 3494.801514 |
| LogP | -5.94 |
| Index of Refraction | 1.644 |