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90880-23-2

90880-23-2 structure
90880-23-2 structure
  • Name: α-Helical CRF(9-41)
  • Chemical Name: α-Helical CRF(9-41)
  • CAS Number: 90880-23-2
  • Molecular Formula: C166H274N46O53S2
  • Molecular Weight: 3826.40
  • Catalog: Signaling Pathways GPCR/G Protein CRFR
  • Create Date: 2020-08-07 22:29:32
  • Modify Date: 2024-01-04 17:58:53
  • α-Helical CRF(9-41) is a competitive CRF2 receptor antagonist with KB of ~100 nM. α-Helical CRF(9-41) is also a partial agonist of CRF1 receptor with an EC50 of 140 nM[1][2].

Name α-Helical CRF(9-41)
Description α-Helical CRF(9-41) is a competitive CRF2 receptor antagonist with KB of ~100 nM. α-Helical CRF(9-41) is also a partial agonist of CRF1 receptor with an EC50 of 140 nM[1][2].
Related Catalog
Target

KB: ~100 nM (CRF2 receptor)[2] EC50: 140 nM (CRF1 receptor)[2]

References

[1]. Sonia Tucci, et al. Corticotropin releasing factor antagonist, alpha-helical CRF(9-41), reverses nicotine-induced conditioned, but not unconditioned, anxiety. Psychopharmacology (Berl). 2003 May;167(3):251-6.

[2]. Smart D, et al. Characterisation using microphysiometry of CRF receptor pharmacology. Eur J Pharmacol. 1999 Aug 27;379(2-3):229-35.

Molecular Formula C166H274N46O53S2
Molecular Weight 3826.40